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HLA Class I and II Alleles in Anti-Acetylcholine Receptor Antibodies Positive and Double-Seronegative Myasthenia Gravis Patients of Romanian Descent.
Neurol Int
December 2024
Department of Immunology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
: Several significant associations between certain Human Leukocyte Antigen (HLA) alleles and myasthenia gravis (MG) subtypes were established in populations from Western Europe and North America and, to a lesser extent, from China and Japan. However, such data are scarcely available for Eastern Europe. This study aimed to analyze the associations of HLA Class I and II alleles with MG and its serological subtypes (with anti-acetylcholine receptor autoantibodies, RAch+MG, and double-seronegative, dSNMG) in myasthenic patients of Romanian descent.
View Article and Find Full Text PDFConformational dynamics of a nicotinic receptor neurotransmitter site.
Elife
December 2024
Computational Biophysics and CADD Group, Computational and Mathematical Biology Center, Translational Health Science and Technology Institute, Faridabad, India.
Agonists enhance receptor activity by providing net-favorable binding energy to active over resting conformations, with efficiency (η) linking binding energy to gating. Previously, we showed that in nicotinic receptors, η-values are grouped into five structural pairs, correlating efficacy and affinity within each class, uniting binding with allosteric activation (Indurthi and Auerbach, 2023). Here, we use molecular dynamics (MD) simulations to investigate the low-to-high affinity transition (L→H) at the Torpedo α-δ nicotinic acetylcholine receptor neurotransmitter site.
View Article and Find Full Text PDFHippocampus encoding memory engrams as stable heteroclinic network.
Chaos
December 2024
School of Mathematics and Statistics, Northwestern Polytechnical University, Xi'an 710129, China.
Article Synopsis
- The brain's transient activity is illustrated through stable heteroclinic channels (SHCs), which represent pathways of memory formation in its dynamic models, with saddle points symbolizing states of brain activity stability.
- The study builds on a model of hippocampal synaptic networks, showing how short-term memories are transformed into long-term memories as trajectories within these channels, affected by neurotransmitter regulation.
- Numerical findings highlight that while noise can disrupt memory clarity, it also aids in the long-term encoding process, providing a dynamic perspective on how memories are structured and retained.
Prolonged Copper Supplementation Modified Minerals in the Kidney, Liver and Blood, and Potentiated Oxidative Stress and Vasodilation of Isolated Aortic Rings in Young Wistar Rats.
Nutrients
September 2024
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
Background: Previous studies have highlighted that copper supplementation at 200% of the recommended daily dietary allowance modified vascular contraction and relaxation through increased reactive oxygen species (ROS) and prostaglandin formation, which modified the antioxidant status of middle-aged Wistar rats.
Methods: In this study, young (1 month old) male Wistar rats (/group = 10) received a diet supplemented with 6.45 mg copper/kg (100% of daily recommendation-Group A) for 8 weeks.
Structural Basis for Histaminergic Regulation of Neural Circuits in the Mouse Olfactory Bulb.
J Comp Neurol
October 2024
Department of Anatomy, Kawasaki Medical School, Kurashiki, Okayama, Japan.
Article Synopsis
- A study examines how histamine-producing neurons from the hypothalamus influence the olfactory bulb (OB), a key area for processing smells.
- Researchers used advanced microscopy techniques to visualize these neurons and their connections, discovering that they have unique synaptic relationships with other neurons in the OB.
- The findings suggest that histamine may play an important role in odor discrimination, highlighting a link between brain regions that control hunger and olfactory function.
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