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Differential expression of plasma extracellular vesicles microRNAs and exploration of their association with bone metabolism in childhood trauma participants treated in a psychosomatic clinic.
Front Endocrinol (Lausanne)
March 2025
Medical Sociology and Psychobiology, University of Potsdam, Potsdam, Germany.
Introduction: Early life stress (ELS) impacts neurotransmitters and cell communication, potentially disrupting neurological and physiological processes. Recently, ELS has been implicated in impaired bone metabolism, with extracellular vesicles (EVs) and their cargo, microRNAs (miRNAs), might affecting this process. This research aimed to elucidate the association between childhood trauma, a specific form of ELS, and bone metabolism through studying miRNA in EVs within three steps: firstly, examining alterations of EV miRNAs between ELS and controls, secondly analyzing associations between altered EV miRNAs and bone markers, and thirdly exploring the target gene prediction and enrichment pathways of altered EV miRNAs.
View Article and Find Full Text PDFSynthesis of Enantiostructured Triacylglycerol Prodrugs Constituting an Active Drug Located at Terminal -1 and -3 Positions of the Glycerol Backbone.
Molecules
February 2025
Science Institute, Chemistry Department, University of Iceland, Dunhaga 3, 107 Reykjavik, Iceland.
The current paper reports the asymmetric synthesis of a focused library of enantiostructured triacylglycerols (TAGs) constituting a potent drug of the NSAID type (ibuprofen or naproxen) along with a pure bioactive n-3 polyunsaturated fatty acid (PUFA) intended as a novel type of prodrug. In this second category, a TAG prodrug of the terminal -1 or -3 position of the glycerol skeleton is acylated with a single saturated medium-chain fatty acid (C6, C8, C10, or C12), and another with the drug entity; the PUFA (EPA or DHA) is located in the -2 position. This was accomplished by a six-step chemoenzymatic approach, two of which were promoted by a lipase, starting from enantiopure ()- and ()-solketals.
View Article and Find Full Text PDFA compact single layer dual band microstrip patch antenna for 5G terminal applications.
Sci Rep
March 2025
LEME, Univ Paris Nanterre, Ville d'Avray, 92410, France.
In modern applications, the shrinking available space on terminals coupled with the increasing number of frequency bands has prompted the greatest demand for antenna miniaturization and multi-band features. This work introduces an innovative method for designing a dual-band planar antenna with an exceptionally compact size, addressing the pressing requirement. Two half-mode patches, both operating in two modes (TM of 3.
View Article and Find Full Text PDFThe role of unbalanced segmental duplication in sex chromosome evolution in Australian ridge-tailed goannas.
Sci Rep
March 2025
Centre for Conservation Ecology and Genomics, Institute for Applied Ecology, Faculty of Science and Technology, University of Canberra, Canberra, ACT, 2601, Australia.
Varanids are known for conserved sex chromosomes, but there are differences in the size of the W chromosome but not in morphology among species representing varying stages of sex chromosome evolution. We tested for homology of the ZW sex chromosome system with size differences in varanids among four species from two lineages in Australia, the Odatria and the Gouldii. We found that while DNA sequences of the sex chromosomes are conserved in the species we tested, we also identified a homologous region on an enlarged autosomal microchromosome that shares sequences with the W chromosome in some isolated populations of V.
View Article and Find Full Text PDFWheat E3 ligase is involved in drought stress tolerance in transgenic .
Physiol Mol Biol Plants
February 2025
Department of Plant Resources, College of Industrial Sciences, Kongju National University, 54 Daehak-Ro, Yesan-Eup, 32439 Republic of Korea.
Unlabelled: , a wheat U-box E3 ligase gene, was isolated and characterized for its role in drought stress tolerance. The gene encodes a 531 amino acid protein with a U-box domain at the N-terminal and a WD40 domain at the C-terminal. Subcellular localization studies using TaPRP19-GFP fusion in confirmed predominant nucleus localization.
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