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Adrenocortical zonation in humans under normal and pathological conditions.
J Clin Endocrinol Metab
May 2010
Department of Urology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Context: Aldosterone synthase (CYP11B2) and steroid 11 beta-hydroxylase (CYP11B1) catalyze the terminal steps for aldosterone and cortisol syntheses, respectively, thereby determining the functional differentiation of human adrenocortical cells. Little is known, however, about how the cells expressing the enzymes are actually distributed in the adrenals under normal and pathological conditions.
Objective: The objective of the study was to determine the localization of CYP11B2 and -B1 in human adrenal specimens by using developed antibodies capable of distinguishing the two enzymes from each other.
Mineralocorticoid and angiotensin receptor antagonism during hyperaldosteronemia.
Hypertension
August 2002
Department of Cardiology, Royal North Shore Hospital, St. Leonards, Sydney, Australia.
Elevated aldosterone levels induce a spironolactone-inhibitable decrease in cardiac sarcolemmal Na+-K+ pump function. Because pump inhibition has been shown to contribute to myocyte hypertrophy, restoration of Na+-K+ pump function may represent a possible mechanism for the cardioprotective action of mineralocorticoid receptor (MR) blockade. The present study examines whether treatment with the angiotensin type 1 receptor antagonist losartan, with either spironolactone or eplerenone, has additive effects on sarcolemmal Na+-K+ pump activity in hyperaldosteronemia.
View Article and Find Full Text PDFEffects of butyrate on active sodium and chloride transport in rat and rabbit distal colon.
J Physiol
February 2002
Department of Gastrointestinal Sciences, Christian Medical College & Hospital, Vellore 632004, India.
Short chain fatty acids, particularly butyrate, stimulate electroneutral NaCl absorption from the colon. Their effect in colonic epithelia lacking basal electroneutral NaCl absorption is unknown. Butyrate is also reported to inhibit active Cl- secretion in the colon.
View Article and Find Full Text PDFHyperaldosteronemia in rabbits inhibits the cardiac sarcolemmal Na(+)-K(+) pump.
Circ Res
August 2000
Department of Cardiology, Royal North Shore Hospital, Sydney, Australia.
Aldosterone upregulates the Na(+)-K(+) pump in kidney and colon, classical target organs for the hormone. An effect on pump function in the heart is not firmly established. Because the myocardium contains mineralocorticoid receptors, we examined whether aldosterone has an effect on Na(+)-K(+) pump function in cardiac myocytes.
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