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Expression Levels of MUC5AC and MUC5B in Airway Goblet Cells Are Associated with Traits of COPD and Progression of Chronic Airflow Limitation.
Int J Mol Sci
December 2024
Research Unit of Biomedicine and Internal Medicine, University of Oulu, 902 20 Oulu, Finland.
Mucins 5AC (MUC5AC) and 5B (MUC5B) are the major mucins providing the organizing framework for the airway's mucus gel. We retrieved bronchial mucosal biopsies and bronchial wash (BW) samples through bronchoscopy from patients with chronic obstructive pulmonary disease ( = 38), healthy never-smokers ( = 40), and smokers with normal lung function ( = 40). The expression of MUC5AC and MUC5B was assessed immunohistochemically.
View Article and Find Full Text PDFEctopic Thymic Tissue Presenting as an Epiglottic Mass Compromising a Neonatal Airway: A Case Report.
Cureus
December 2024
Division of Otolaryngology, Department of Surgery, Nemours Children's Health System, Wilmington, USA.
An epiglottic mass (EM) is rarely found in neonates and poses life-threatening airway complications. We present the case of an infant urgently transferred from Belize via the World Pediatric Project with a lingual EM. The EM was misdiagnosed twice.
View Article and Find Full Text PDFBioinspired Liquid Pockets with Externally Induced Internal Microscale Flow.
Adv Mater
January 2025
School of Life Sciences, Xiamen University, Xiamen, 361102, China.
The gastric mucosal barrier, through its gastric pits, serves as a pathway for secretions, ensuring that mucus produced by the gastric glands is transferred to the gastric lumen, providing stable protection. Here a bioinspired liquid pockets material is shown, composed of a thermo-driven hydrogel that acts as an external activation unit to release interflowing liquid responsively, and porous matrices that serve as interconnected pockets to transfer it, enabling controlled internal flow and adaptive barrier functionality. Experiments and theoretical analysis demonstrate the stability and regulatory mechanisms of these liquid pockets, based on the interconnected pockets between the external activation unit and internal fluid flow.
View Article and Find Full Text PDFIn Search of Candidate Protein Biomarkers Related to COVID-19 in Solid Tissues and Non-Blood Fluids: An Update.
Proteomics Clin Appl
December 2024
Department of Medical and Clinical Biophysics, Faculty of Medicine, University of P.J. Šafárik in Košice, Košice, Slovakia.
Purpose: During COVID-19, significant changes in protein abundance can be linked with disease-related processes. The mass spectrometry-based proteomics of COVID-19-related biomarkers can help with the prognosis and diagnosis of this severe disease.
Design: Here, we surveyed scientific works in terms of proteomic analysis of solid tissues and non-blood fluids from COVID-19 patients.
Oral Rehabilitation of a Child Superimposed with Tooth Impaction and Ranula.
Int J Clin Pediatr Dent
September 2024
Department of Pediatric Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Pediatric Dentistry and Dental Public Health, Alexandria University, Alexandria, Egypt.
Introduction: Dental impaction may be due to several etiological factors, including genetic conditions, lack of space, failure of primary tooth resorption and prolonged retention of these teeth, presence of intraosseous cysts, and trauma in the region. The ranula is a mucus-filled cyst-like mass that usually originates from extravasation of mucus from the sublingual gland.
Case Description: A 7-year-old Saudi female presented to the pediatric dental clinic at Prince Mohammed Bin Abdulaziz Hospital (PMBAH), Al-Madinah al-Munawwarah, Saudi Arabia, with complicated orodental problems that were identified after clinical and radiological assessment, including the following: an intruded primary central incisor in close relation to the nasal cavity, hypodontia, hypomineralization, multiple carious teeth, abscess, and sublingual ranula.
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