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Background Research on nursing care needs (NCNs) for critically ill patients at discharge is scarce. This study aimed to quantify and compare NCNs at discharge between patients with severe COVID-19 and septic shock and to identify factors associated with higher NCNs. Methodology We retrospectively analyzed data from the Diagnosis Procedure Combination database between April 1, 2020, and March 31, 2023, on patients requiring ventilators in the intensive care unit (ICU).
View Article and Find Full Text PDFInfluence of sequential blood purification therapy on myocardial injury and serum inflammatory cytokine levels in patients with organophosphate poisoning.
Am J Transl Res
October 2024
Department of Emergency, Anxi County Hospital Quanzhou 362400, Fujian, China.
Article Synopsis
- The study aimed to assess the effects of sequential blood purification therapy on heart injury and inflammation in patients with organophosphorus poisoning, comparing two treatment regimens.
- A total of 67 patients were analyzed; one group received conventional treatment with hemoperfusion, while the other received the same plus continuous veno-venous hemofiltration (research group).
- Results showed the research group had better outcomes, including a higher effective treatment rate, quicker recovery times, and lower inflammatory and myocardial injury markers compared to the control group.
The Donnan equilibrium is still valid in high-volume HDF.
Int J Artif Organs
December 2024
Global Systems Engineering, VS Machines, Care Enablement, Fresenius Medical Care Deutschland GmbH, Schweinfurt, Bavaria, Germany.
Clinical studies have shown that hemodiafiltration reduces morbidity and mortality of dialysis patients compared to hemodialysis alone. This is attributed to its superior middle molecule clearance compared to standard hemodialysis. However, doubts arose as to whether a high convective flux through the dialyzer membrane has an influence on the equilibrium concentration of small ions, especially that of sodium.
View Article and Find Full Text PDFAbsolute blood volume and long-term survival in chronic hemodialysis patients.
Int J Artif Organs
December 2024
KfH Kidney Center Berlin-Köpenick, Berlin, Germany.
Current online hemodiafiltration devices can be used to determine the absolute blood volume in clinical practice using the dialysate bolus method. Most of publications on this method have focused on preventing intradialytic complications. The influence of absolute blood volume on long-term prognosis has not been reported yet.
View Article and Find Full Text PDFEdoxaban pharmacokinetics during in vitro continuous renal replacement therapy.
BMC Nephrol
October 2024
Department of Pharmacy Practice, College of Pharmacy, MHPE, BCPS - AQ Cardiology, FCCM, FCCP, University of Illinois at Chicago, 833 South Wood Street, Room 164 (M/C 886), Chicago, IL, 60612, USA.
Article Synopsis
- - Edoxaban was tested for its clearance during continuous renal replacement therapy (CRRT) by analyzing its levels in pre- and post-filter blood samples, using methods like liquid chromatography for accurate measurement.
- - The study found that edoxaban clearance was primarily due to its adsorption to specific hemofilters, with a confirmed average protein binding of 41%, and multivariate analysis showed that the CRRT setup had little effect on clearance rates.
- - The recommended dosing for edoxaban is 30-45 mg once daily, depending on the flow rate of the CRRT system, to achieve the necessary drug exposure for treating venous thromboembolism.
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