AI Article Synopsis
- Researchers used the left and right halves of adenovirus type 2 and a hybrid adenovirus to investigate where DNA replication starts.
- The findings support multiple models, suggesting that replication could initiate from both ends of the DNA molecules.
- The replication process appears to be bidirectional, meaning it extends in both directions from the starting point.
Article Abstract
Utilizing the isolated left and right halves of both adenovirus type 2 and the nondefective adenovirus simian virus 40 hybrid (Ad2(+)ND(1)), studies were undertaken to find the site on the DNA molecules at which replication begins. The data are consistent with several models which include an initiation event at both ends and bidirectional growth.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC355413 | PMC |
| http://dx.doi.org/10.1128/JVI.13.5.1046-1054.1974 | DOI Listing |
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