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QRFP43 modulates the activity of the hypothalamic-pituitary-thyroid axis in female sheep.
Sci Rep
January 2025
Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, Jabłonna, 05-110, Poland.
Since the early discovery of QRFP43, intensive research has been primarily focused on its role in the modulation of food intake. As is widely recognised, the regulation of the body's energy status is a highly complex process involving numerous systems, hormones and neurotransmitters. Among the most important regulators of energy status, alongside the satiety and hunger centre located in the hypothalamus, is the HPT axis, which directly and indirectly affects the regulation of metabolism in all cells of the body.
View Article and Find Full Text PDFA Sensitive Radioimmunoassay for T3 and T4 Determinations in Plasma and Tissues.
Methods Mol Biol
November 2024
Laboratory of Thyroid Hormones and Central Nervous System, Department of Neurological Diseases and Aging, Instituto de Investigaciones Biomédicas Sols-Morreale, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
This chapter details protocols for determining plasma thyroid hormone (TH) levels and tissue TH content by competitive radioimmunoassays (RIAs). These protocols include: an initial test of the chromatographic performance, isotopic labeling to produce high activity I-T3 and I-T4, free iodide estimation of the labeled products, purification of tracers from iodide by paper electrophoresis, extraction of THs from plasma and tissue samples, and the RIA procedures. The RIA involves the competition between radioactive labeled and unlabeled hormones for specific antibody binding, and due to its high sensitivity is capable of detecting a minimum of 2.
View Article and Find Full Text PDFThe COVID-19 legacy: consequences for the human DNA methylome and therapeutic perspectives.
Geroscience
November 2024
Institute for Systems Analysis and Computer Science, National Research Council (CNR)-IASI, 00185, Rome, Italy.
The COVID-19 pandemic has left a lasting legacy on human health, extending beyond the acute phase of infection. This article explores the evidence suggesting that SARS-CoV-2 infection can induce persistent epigenetic modifications, particularly in DNA methylation patterns, with potential long-term consequences for individuals' health and aging trajectories. The review discusses the potential of DNA methylation-based biomarkers, such as epigenetic clocks, to identify individuals at risk for accelerated aging and tailor personalized interventions.
View Article and Find Full Text PDFmiR-210 as a therapeutic target in diabetes-associated endothelial dysfunction.
Br J Pharmacol
January 2025
Division of Cardiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Article Synopsis
- This study investigates the role of microRNA (miR)-210 in endothelial cells and its potential therapeutic effects on diabetes-related endothelial dysfunction.* -
- Using various mouse models and human endothelial cells, researchers discovered that lower levels of miR-210 in diabetic conditions impair endothelium-dependent relaxation (EDR), but restoring its levels helps improve vascular function.* -
- The findings suggest miR-210 could be a new target for treatment in type 2 diabetes by mitigating oxidative stress and enhancing nitric oxide production in endothelial cells.*
Prediction of COVID-19 severity using machine learning.
Clin Transl Med
October 2024
Cardiovascular Research Unit, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg.
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