A fluorescent urinary metabolite, excreted by mice carrying the Ehrlich ascites tumour (EAT), has been identified as 7,8-dihydro-6-hydroxylumazine. This finding agrees with other data which show that a disorder in pteridine metabolism is commonly associated with the presence of malignant growth.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0304-3835(79)80001-4DOI Listing

Publication Analysis

Top Keywords

ehrlich ascites
8
ascites tumour
8
enhanced urinary
4
urinary excretion
4
excretion 78-dihydro-6-hydroxylumazine
4
78-dihydro-6-hydroxylumazine mice
4
mice bearing
4
bearing ehrlich
4
tumour fluorescent
4
fluorescent urinary
4

Similar Publications

Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors.

Pharmaceuticals (Basel)

December 2024

Post Graduate Program in Structural and Functional Biology, Paulista School of Medicine (UNIFESP-EPM), Federal University of São Paulo, São Paulo 04023-062, SP, Brazil.

is traditionally known for its medicinal properties. Objectives: Here, we investigated the effects of crude extract (CE) and ethyl acetate fraction (EAF) obtained from leaves on the ascitic (EA) and solid (ES) forms of Ehrlich tumors. : Induced and uninduced BALB/c mice were treated intramuscularly, for 7 or 14 days, with saline solution or CE and EAF, both at a 10% concentration, based on in vitro cytotoxicity assessment.

View Article and Find Full Text PDF

Being the second leading cause of death globally, cancer has been a long-standing and rapidly evolving focus of biomedical research and practice in the world. Recently, there has been growing interest in cyanobacteria. This focus is particularly evident in developing innovative anticancer treatments to reduce reliance on traditional chemotherapy.

View Article and Find Full Text PDF

Numerous chemotherapeutic agents are currently employed in cancer treatment, but many are associated with significant side effects. This study aims to identify a novel anticancer drug that minimizes or eliminates these adverse effects. The anticancer activity of the Rhodium (III) complex cis-[RhLI]I was evaluated through both in vivo and in vitro functional assays.

View Article and Find Full Text PDF

Two new thiadiazole imidazolium salicylidene Schiff bases (TISSBs) were successfully synthesized, and their structures were analyzed comprehensively using spectroscopic techniques. The results of the MTT assay showed that TISSB2 was the safest and most effective anti-breast cancer agent. The anti-angiogenic activity of TISSB2 was evaluated using tests in Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!