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Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions.
Acta Otolaryngol
September 2012
Otorhinolaryngology Service, Hospital Comarcal de El Bierzo Ponferrada, Spain.
Conclusion: The cochlear perilymphatic perfusion produces, by itself, significant effects in the cochlear physiology that could be associated with the surgical procedure. These effects need to be well characterized to allow a reliable quantification of the effects of the experimental agent being tested.
Objectives: The study focused on the accurate description of the electrophysiological effects on the cochlear potential recordings of perilymphatic perfusions.
The systemic application of diazepam facilitates the reacquisition of a well-balanced vestibular function in a unilateral vestibular re-input model with intracochlear tetrodotoxin infusion using an osmotic pump.
Brain Res
June 2006
Department of Otolaryngology, Yamaguchi University School of Medicine, Ube, Japan.
Diazepam is a popular medicine used in the treatment of acute vertigo. In the past, many studies investigating the effect of diazepam in peripheral vestibular destruction have been reported. However, no previous study has yet investigated the effect of diazepam on a model with a transient and reversible vestibular function similar to recurrent vertigo as seen in Meniere's disease.
View Article and Find Full Text PDFEffect of nicotine on cochlear function and noise-induced hair cell loss.
Ann Otol Rhinol Laryngol
July 1976
Nicotine administered in high doses intravenously (1 mg/kg) and intracochlearly (10 mM) exhibited very little effect on guinea pig cochlear potentials. When administered chronically (1-20 mg/kg, i.p.
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