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Kallikrein effect on the acquisition and extinction of conditioned reflexes in rats.
Acta Physiol Pol
January 1987
The effect of kallikrein was studied on the acquisition and extinction of conditioned reactions in rats. It was demonstrated that kallikrein in doses of 50 and 100 mu/kg i.p.
View Article and Find Full Text PDFProstaglandin E1 (PGE1) slightly inhibited the amphetamine (AMPH) induced stereotypy after administration of bradykinin (BRS) or stimulation the activity of kininogenic enzymes of the cerebral tissue by kallikrein administration. After administration of PGE1, BRS did not affect the apomorphine (APO)-induced stereotypy. The effect of kinins on catalepsy induced by haloperidol (HAL) was changed depending on the dose of PGE1.
View Article and Find Full Text PDFThe effect of intraventricularly (ivc) administered bradykinin (BRS) and activation of kininogenic enzymes of the cerebral tissue by kallikrein on dopaminergic system was investigated in tests of amphetamine (AMPH) and apomorphine (APO)-induced stereotypy and haloperidol (HAL)-induced catalepsy in rats receiving an inhibitor of prostaglandin synthetase, indomethacin (IND). The cerebral content of dopamine (DA), noradrenaline (NA) and homovanillic acid (HVA) was determined after some dosage schedules. In rats pretreated with IND the action of AMPH was potentiated and modulated by kinins (depending on the dose).
View Article and Find Full Text PDFThe influence exerted by a number of non-steroid antiphlogistic agents on the fermentative mechanism responsible for the formation and decomposition of kininines in an inflammation focus and on the permeability of vessels in a skin changed under the effect of exogenous bradykininine was studied. Bradykininine, chigamin, sodium salicylate and mephenaminate are shown to inhibit "in vitro" the kininogenic and intensify the kininase activity of the exudate in rats with turpentine-induced pleuritis, while indometacin affects only the activity of kininogenases. Butadion, chingamin and sodium mephenaminate merely reduce the reactivity of the skin with respect to exogenous bradykininine.
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