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Is the adrenal cortex a target for gonadotropins?
Trends Endocrinol Metab
September 2008
Department of Reproductive Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
The human adrenal cortex expresses low levels of luteinizing hormone/chorionic gonadotropin receptors (LHCGR), a characteristic gonad-specific G-protein coupled receptor (GPCR). LHCGR levels increase in the adrenal cortex after exposure to chronically elevated gonadotropins (e.g.
View Article and Find Full Text PDFAdrenocortical tumorigenesis, luteinizing hormone receptor and transcription factors GATA-4 and GATA-6.
Mol Cell Endocrinol
April 2007
Department of Physiology, University of Turku, FIN-20520 Turku, Finland.
Luteinizing hormone (LH/hCG) responsiveness of normal and pathological human adrenal glands as well as the possibility of constitutive expressions of luteinizing hormone receptor (LHR) in adrenal cortex has been reported. Some recent studies showed a correlation between the LHR and abundant GATA-4 expression in both metastasizing and non-metastasizing human adrenocortical tumors, but not in normal adrenals, implicating the putative relevance of LHR and GATA-4 for adrenocortical pathophysiology. However, the physio- and pathophysiological significance of LHR and GATA-4 in the mechanism of adrenocortical tumorigenesis remains unclear.
View Article and Find Full Text PDFTestosterone-secreting gonadotropin-responsive adrenal adenoma and its treatment with the antiandrogen flutamide.
J Endocrinol Invest
September 2001
City Hospital, Kiskunfélegyháza, Hungary.
A 55-year-old woman with virilization had an appreciably elevated testosterone level, which was not suppressed by dexamethasone, but was increased by stimulation with human chorionic gonadotropin (hCG). Ultrasonography and computed tomography revealed an adenoma 2.5-3.
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