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Protective role of Pannexin1 in lymphatic endothelial cells in the progression of atherosclerosis in female mice.
PLoS One
January 2025
Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Atherosclerosis is a progressive arterial disease arising from imbalanced lipid metabolism and a maladaptive immune response. The lymphatic system ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells to draining lymph nodes, thereby potentially affecting atherogenesis. Endothelial cell-specific deletion of Pannexin1 (Panx1) in apolipoprotein E-deficient (Apoe-/-) mice increased atherosclerosis, suggesting a protective role for Panx1 channels in arterial endothelial function.
View Article and Find Full Text PDFHigher epicardial adipose tissue volume is associated with higher coronary fatty plaque volume and is regulated by waist circumference but not EPA+DHA supplementation.
J Clin Lipidol
November 2024
Division of Cardiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, United States (Drs Amangurbanova, Asbeutah, Vemuri, Mirza, Waseem, Malik, Welty). Electronic address:
Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation lower triglyceride levels. The impact on epicardial adipose tissue volume (EATV), which is associated with cardiovascular events, is unclear.
Objective: To determine if triglyceride reduction with EPA+DHA supplementation decreases EATV and whether EATV affects coronary plaque.
Rice bran active peptide (RBAP) inhibited macrophage differentiation to foam cell and atherosclerosis in mice via regulating cholesterol efflux.
Phytomedicine
September 2024
Molecular Nutrition Branch, National Engineering Research Center of Rice and By-product Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, PR China. Electronic address:
Article Synopsis
- Atherosclerosis is a chronic inflammatory condition in arteries, with recent studies indicating the importance of cholesterol removal pathways and the role of an anti-inflammatory agent called RBAP in this context.
- The research investigates how RBAP affects cholesterol efflux, using a mouse model with a high-fat diet to assess its effects through oral and injection methods, along with in vitro experiments on macrophage cells.
- Findings show that RBAP reduces inflammation markers and enhances cholesterol removal, with mechanisms involving the TLR4/MyD88/NF-κB signaling pathway, implying potential therapeutic benefits in managing atherosclerosis.
Role of Omega-3 fatty acids eicosapentaenoic (EPA) and docosahexaenoic (DHA) as modulatory and anti-inflammatory agents in noncommunicable diet-related diseases - Reports from the last 10 years.
Clin Nutr ESPEN
October 2024
Poznan University of Medical Sciences, Department of Bromatology, Rokietnicka 3, Poznan, Poland.
Background & Aims: Fatty acids are a fundamental component of the human diet, particularly polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The importance of omega-3 fatty acids has been studied in the context of many diseases due to their pleiotropic effects, focusing on the anti-inflammatory effects of EPA and DHA. Currently, the results of these acids in noncommunicable diseases are being increasingly assessed in a broader context than just inflammation.
View Article and Find Full Text PDFSesame oil downregulates the expression of ADAMTS-4 in high-fat diet-induced atherosclerosis.
Prostaglandins Other Lipid Mediat
October 2024
Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala 695581, India. Electronic address:
Atherosclerosis is a chronic inflammatory disease forming plaques in medium and large-sized arteries. ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs-4) is an extracellular-matrix remodelling enzyme involved in the degradation of versican in the arterial wall. Recent reports indicated that increased expression of ADAMTS-4 is associated with plaque progression and vulnerability.
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