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Exploring the reproductive exposure risks of phthalates and organophosphates in atmospheric particulate matter based on quantitative structure-activity relationships and network toxicology models.
J Hazard Mater
January 2025
SKL-ESPC and BIC-ESAT, College of Environmental Sciences and Engineering, Peking University, Beijing, China. Electronic address:
Minimal study focused on the association between mixed pollutants in atmospheric particulate matter (PM) and their reproductive health risks. Utilizing a novel quantitative structure-activity relationship (QSAR) integrated machine learning algorithms, we evaluated the mixed reproductive health risks associated with phthalates (PAEs) and organophosphates (OPEs) exposure by assessing the affinities of these compounds binding to estrogen receptors (ER) and androgen receptors (AR). The mixed toxicity equivalent factor (TEF) and mixed toxicity equivalent quantity (TEQ) by the QSAR model were all smaller than the sum TEF and TEQ of individual PAEs and OPEs, which may be due to the antagonistic effect of PAEs and OPEs monomers on reproductive toxicity.
View Article and Find Full Text PDFThe Mark Cuban Cost Plus Drug Company Effect on Urogynecologic Drugs.
Urogynecology (Phila)
January 2025
From the Department of Urology, Atrium Health Wake Forest Baptist, Winston-Salem, NC.
Importance: The Mark Cuban Cost Plus Drug Company (ie, Cost Plus Drugs) is a service that makes generic drugs affordable. Cortese et al recently published the top 9 most commonly used oral medications in treatment of urologic conditions and showed that Cost Plus Drugs would have provided an estimated $1.29 billion reduction in 2020 costs if they replaced the Medicare prices.
View Article and Find Full Text PDFBisphenol A concentration in canned fruits and vegetables and their risk assessment using Monte Carlo simulation in Iran.
Sci Rep
December 2024
Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics, which has risks for human health. This study aimed to investigate BPA contents in canned fruit and vegetable samples using Gas Chromatography-Mass Spectrometry (GC-MS). Furthermore, health risks were assessed for Iranian adults and children using Monte Carlo simulations.
View Article and Find Full Text PDF[Construction of a 17-estradiol sensor based on a magnetic graphene oxide/aptamer separating material].
Se Pu
January 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
17-Estradiol (E2) is a natural steroidal estrogen essential for a variety of physiological functions in organisms. However, external E2, which is renowned for its potent biological effects, is also considered to be an endocrine-disrupting compound (EDC) capable of disturbing the normal operation of the endocrine system, even at nanogram-per-liter (ng/L) concentrations. Studies have revealed that medical and livestock wastewater can be contaminated with E2, which poses potential risks to human health.
View Article and Find Full Text PDFA comprehensive review on advanced trends in treatment technologies for removal of Bisphenol A from aquatic media.
Environ Monit Assess
December 2024
Department of Metallurgical and Material Engineering, Karadeniz Technical University, 61080, Trabzon, Turkey.
Toxic environmental pollutants are considered to be posed a major threat to human and aquatic systems. The fast advancement of the petrochemical and chemical industries has woken up rising worries concerning the pollution of water by contaminants including phenolic Bisphenol A (BPA), an endocrine-disrupting chemical (EDC). The intermediate BPA used in synthesis of certain plastics, polycarbonate polymers, polysulfone, and epoxy resins of various polyesters.
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