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Enzymatic grafting of 5-O-succinyl erythorbyl myristate onto chitosan to improve its emulsifying properties.
Carbohydr Polym
March 2025
Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Republic of Korea; Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea; Center for Agricultural Microorganism and Enzyme, Seoul National University, Seoul 08826, Republic of Korea; Center for Food and Bioconvergence, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:
Chitosan (CS) is a versatile polysaccharide with numerous inherent biological activity, while the lack of amphiphilicity limits its application in emulsion-based systems. In this study, erythorbyl myristate (EM) with interfacial activity was chemically modified to 5-O-succinyl EM (EMS) and grafted onto CS to improve the emulsifying properties. The grafting reaction was conducted by the catalysis of protease, with the progress of the reaction monitored by HPLC analysis and UV absorbance measurement.
View Article and Find Full Text PDFCross-linked chitosan encapsulated hollow mesoporous silica nanoparticle: A dual-functional smart nanocapsule design for targeted corrosion inhibition and controlled emulsification.
Carbohydr Polym
March 2025
School of Materials Science and Engineering, China University of Petroleum (East China), Qingdao 266580, China; Institute of Advanced Materials, China University of Petroleum (East China), Qingdao 266580, China.
Research on stimuli-responsive micro-nanocontainers has gained attention for targeted corrosion inhibition and controlled emulsification-demulsification in oil recovery. However, existing nanocontainers face issues like irreversible drug release and limited functionality. This study presents a multi-functional nanocontainer design with reversible drug release and emulsification-demulsification capabilities.
View Article and Find Full Text PDFPOLYSORBATE 80 AND CARBOXYMETHYLCELLULOSE: A DIFFERENT IMPACT ON EPITHELIAL INTEGRITY WHEN INTERACTING WITH THE MICROBIOME.
Food Chem Toxicol
January 2025
Department of Food Biotechnology and Microbiology, Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM), Nicolás Cabrera 9, 28049 Madrid, Spain. Electronic address:
The consumption of dietary emulsifiers, including polysorbate 80 (P80) and sodium carboxymethylcellulose (CMC), has raised safety concerns due to its interaction with the intestinal microbiome. This study demonstrated that increasing concentrations of P80 and CMC added to a dynamic four-stage gut microbiota model (BFBL gut simulator) altered the microbiome composition and impacted epithelial integrity in a dose-dependent manner. 16S rDNA amplicon-based metagenomics analysis revealed that these emulsifiers increased microbial groups with proinflammatory capacities while decreasing microbial taxa known to enhance barrier function.
View Article and Find Full Text PDFOral delivery of MOMIPP lipid nanoparticles for methuosis-induced cancer chemotherapy.
Nanoscale
January 2025
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Methuosis, a non-apoptotic pattern of cell death, triggers the accumulation of macropinosome-derived vacuoles in the cytoplasm. Through this novel mechanism, methuosis inducers possess great potential in fighting apoptosis-resistant cancer cells and offer a promising alternative for cancer treatment. However, the potent methuosis inducer, 3-(5-methoxy, 2-methyl-1-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one (MOMIPP), faces an intractable issue of insolubility in most solvents, hindering dosing and compromising the validation of its antitumor efficacy.
View Article and Find Full Text PDFEfficient Encapsulation and Controlled Release of the Pesticide Emamectin Benzoate in Polylactic Acid Microspheres Prepared by Modified Solvent Evaporation.
Molecules
December 2024
Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Emamectin benzoate (EB) is a highly effective broad-spectrum insecticide and acaricide. However, because EB is easily degraded, the conventional formulations of EB are often overapplied. In this study, polylactic acid (PLA)-based microspheres were prepared using the modified solvent evaporation method for the controlled release of EB.
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