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Characteristic Structure of the Relationships Among Depression, Maladaptive Cognition, and Internet Addiction and Its Temporal Evolution in University Students: A Network Analysis.
Stress Health
February 2025
Collaborative Innovation Center of Assessment Toward Basic Education Quality, Beijing Normal University, Beijing, China.
This study explored the structure and temporal evolution of the relationship among depression, maladaptive cognition, and internet addiction (DMI) among university students by focusing on topological and dynamic properties in a network analysis. A 3-year longitudinal survey was conducted with 873 university students (M = 18.32, SD = 0.
View Article and Find Full Text PDFTotal Synthesis of the Tridecasaccharide Motif from Angelica sinensis APS-1 II Polysaccharide with Anti-leukemia Activity and Structure-Activity Relationship Studies.
Angew Chem Int Ed Engl
January 2025
Kunming Institute of Botany Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Plant Resources in West China, 132 Lanhei Road, 650201, Kunming, CHINA.
A polysaccharide APS-1 II from a medicinal plant Angelica sinensis represents an interesting therapeutic agent against leukemia. However, the synthetic accessibility of the highly branched and complex APS-1 II polysaccharide with multiple 1, 2-cis-glycosidic linkages remains a difficult task, impeding the in-depth structure-activity relationship biological studies and the development of carbohydrates-based therapeutics against leukemia. Here, we report the first chemical synthesis of tridecasaccharide repeating unit together with shorter sequences 4-mer, 6-mer and 9-mer from APS-1 II polysaccharide via one-pot orthogonal glycosylation strategy based on glycosyl ortho-(1-phenylvinyl)benzoates, which precluded the potential issues such as aglycone transfer associated with one-pot assembly with thioglycosides.
View Article and Find Full Text PDFLAG Time in the Era of Immunotherapy-New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene-3.
Immunol Rev
March 2025
Department of Immunology, Moffitt Cancer Center, Tampa, Florida, USA.
The immune checkpoint receptor lymphocyte activation gene-3 (LAG3) inhibits T-cell activation and was recently validated as a target for cancer immunotherapy. Despite its emergence as a therapeutic target, a lack of molecular-level insight has obscured our understanding of the LAG3 immunosuppression mechanism. This review highlights a series of breakthroughs that have illuminated fundamental aspects of LAG3 molecular biology.
View Article and Find Full Text PDFCharacteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases.
FEBS Lett
January 2025
School of Science, STEM College, RMIT University, Melbourne, Australia.
The Kelch protein superfamily is an evolutionary conserved family containing 63 alternate protein coding members. The superfamily is split into three subfamilies: Kelch like (KLHL), Kelch-repeat and bric-a-bracs (BTB) domain containing (KBTBD) and Kelch domain containing protein (KLHDC). The KLHDC subfamily is one of the smallest within the Kelch superfamily, containing 10 primary members.
View Article and Find Full Text PDFPharmacovigilance Indicators in Health Services: A Systematic Review. Are There Still Relevant Gaps?
J Patient Saf
February 2025
Faculty of Pharmacy, Federal University of Rio de Janeiro.
Objective: The aim of this study was to identify potentially applicable pharmacovigilance (PV) indicators for health services available in the literature.
Methods: We searched MEDLINE, EMBASE, LILACS, IBECS, CUMED, SciELO, and Google Scholar bibliographic between January 1, 2004 and January 23, 2023, and 25 websites from different organizations for studies describing specific PV indicators in health services. The methodological quality of the included studies was assessed using the Appraisal of Indicators through the Research and Evaluation (AIRE) tool.
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