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SNAP25 as a prognostic marker in transcriptome analysis of meningioma.
Lab Med
November 2024
Department of Laboratory Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200011, China.
Background: Meningiomas are the most common intracranial tumors and their diagnosis relies mostly on neuroimaging and histology. However, the histology grades cannot predict the outcome exactly and some meningiomas tend to recur after resection of even benign tumors. Therefore, it is necessary to explore prognostic and diagnostic molecular targets.
View Article and Find Full Text PDFIdentification and RT-qPCR Validation of Biomarkers Based on Butyrate Metabolism-Related Genes to Predict Recurrent Miscarriage.
J Inflamm Res
October 2024
Department of Dermatology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang, People's Republic of China.
Purpose: To date, the cause of recurrent miscarriage (RM) in at least 50% of patients remains unknown. However, no study has explored the correlation between butyrate metabolism-related genes (BMRGs) and RM.
Methods: RM-related datasets (GSE165004, GSE111974, GSE73025, and GSE179996) were obtained from the Gene Expression Omnibus (GEO) database.
Munc18c accelerates SNARE-dependent membrane fusion in the presence of regulatory proteins α-SNAP and NSF.
J Biol Chem
March 2024
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China. Electronic address:
Intracellular vesicle fusion is driven by the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and their cofactors, including Sec1/Munc18 (SM), α-SNAP, and NSF. α-SNAP and NSF play multiple layers of regulatory roles in the SNARE assembly, disassembling the cis-SNARE complex and the prefusion SNARE complex. How SM proteins coupled with NSF and α-SNAP regulate SNARE-dependent membrane fusion remains incompletely understood.
View Article and Find Full Text PDFExploring the conformational changes of the Munc18-1/syntaxin 1a complex.
Protein Sci
December 2023
Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Article Synopsis
- Neurotransmitters are released from synaptic vesicles when calcium enters, triggering membrane fusion driven by a complex of SNARE proteins.
- The neuronal protein Munc18-1 stabilizes a SNARE protein (syntaxin-1a), preventing complex formation, but is crucial for neurotransmitter release in living organisms.
- By using mutations to alter the binding complex and molecular dynamics simulations, the researchers created a model suggesting a new conformation of syntaxin-1a that allows SNARE complex formation while still attached to Munc18-1, warranting further investigation into how other proteins regulate this process.
Biotransformation of 2,4,6-trinitrotoluene by Diaphorobacter sp. strain DS2.
Environ Sci Pollut Res Int
December 2023
Department of Environmental Hydrology and Microbiology, The Zuckerberg Institute for Water Research, The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sde Boker Campus 8490000, Be'er Sheva, Israel.
Diaphorobacter strain DS2 degrades 3-nitrotoluene and 2-nitrotoluene via ring oxidation with 3-nitrotoluene dioxygenase (3NTDO). In the current study, we hypothesized that 3NTDO might also be involved in the degradation of 2,4,6-trinitrotoluene (TNT), a major nitroaromatic explosive contaminant in soil and groundwater. Strain DS2 transforms TNT as a sole carbon and nitrogen source when grown on it.
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