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Bee venom (BV) represents a promising natural alternative to conventional antibiotics, particularly significant given its broad-spectrum antimicrobial activity and potential to address the growing challenge of antimicrobial resistance. The prevalence of antimicrobial-resistant microorganisms (AMR) is a global burden that affects human health and the economies of different countries. As a result, several scientific communities around the world are searching for safe alternatives to antibiotics.

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Despite the various medications used in clinics, the efforts to develop more effective treatments for depression continue to increase in the past decades mainly because of the treatment-resistant population, and the testing of several hypotheses- and target-based treatments. Undesirable side effects and unresponsiveness to current medications fuel the drive to solve this top global health problem. In this study, we focused on neuroinflammatory response-mediated depression which represents a cluster of depression etiology both in animal models and humans.

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Molecular basis for hycanthone drug action in schistosome parasites.

Mol Biochem Parasitol

March 2020

Department of Biochemistry & Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States; X-Ray Crystallography Core Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States. Electronic address:

Hycanthone (HYC) is a retired drug formerly used to treat schistosomiasis caused by infection from Schistosoma mansoni and S. haematobium. Resistance to HYC was first observed in S.

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Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis.

PLoS One

October 2019

Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Article Synopsis
  • Researchers developed a high-throughput screening assay to find effective drug combinations for cancer treatment using platinum-based chemotherapy and a library of 1280 diverse compounds.
  • The assay focused on chemoresistant lung and pancreatic cancer cell lines and identified several new synergistic combinations that included non-traditional anticancer drugs.
  • The study revealed that some non-cancer drugs also showed strong interactions with platinum-based therapies, suggesting that innovative combinations can be found beyond conventional methods.
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Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library.

Antibiotics (Basel)

September 2015

Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

Lyme disease is a leading vector-borne disease in the United States. Although the majority of Lyme patients can be cured with standard 2-4 week antibiotic treatment, 10%-20% of patients continue to suffer from prolonged post-treatment Lyme disease syndrome (PTLDS). While the cause for this is unclear, persisting organisms not killed by current Lyme antibiotics may be involved.

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