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Insights from animal studies exploring the efficacy and safety of topical losartan, in prophylaxis and treatment of corneal scarring fibrosis.
Biomed Pharmacother
January 2025
The Cole Eye Institute, The Cleveland Clinic, Cleveland, OH 44195, United States. Electronic address:
Several studies in rabbits demonstrated the efficacy and safety of topical losartan, an angiotensin II receptor blockers (ARB) that modulates the TGF-β intracellular signaling pathways by inhibiting the activation of Extracellular Signal-regulated Kinase (ERK), in preventing or treating stromal fibrosis after a range of injuries such as Descemetorhexis, alkali burns, incisions, and photorefractive keratectomy (PRK). Several case reports have shown that topical losartan treatment is also efficacious and safe in humans to prevent or treat stromal fibrosis after many different injuries or diseases. Topical losartan penetrates the full thickness of the cornea and, therefore, can treat both anterior and posterior stromal fibrosis.
View Article and Find Full Text PDFComprehensive surgical management of a severe 270-degree circumferential penetrating neck injury from an industrial accident: a case report.
J Surg Case Rep
December 2024
Anesthesia Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, Najaf Road, 51001, Hilla, Iraq.
Penetrating neck injury (PNI), involving disruption of the platysma muscle, accounts for 10% of trauma cases and poses significant morbidity and mortality risks. This case report details the management of a 45-year-old male who sustained a 270-degree circumferential neck incision from an industrial accident. The patient presented with a deep neck laceration, severe blood loss, and hypovolemic shock.
View Article and Find Full Text PDFFeasibility and Safety of the C1 "Zero Angle" Screw: A Novel "In-Out-In" Technique for Atlantoaxial Dislocation.
Orthop Surg
December 2024
The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Objectives: To minimize the risk of V3 segment of vertebral artery (VA) injury in the atlantoaxial dislocation (AAD) patients with C1 pedicle height less than 4.0 mm and provide a strong toggle force in irreducible AAD and revision surgery. We evaluated the feasibility of C1 "Zero Angle" screw (C1ZAS) and safe entry point with "in-out-in" technique as an alternative option for C1 pedicle screw (PS) in cases with AAD.
View Article and Find Full Text PDFMaternal and neonatal outcomes of occiput posterior vaginal delivery.
J Obstet Gynaecol Res
January 2025
Perinatal Center for Maternity and Neonates, Yokohama City University Medical Center, Yokohama City, Kanagawa, Japan.
Article Synopsis
- The study investigates the maternal and neonatal outcomes of fetal occiput posterior (OP) deliveries in Japan, as OP positions are often linked to worse maternal outcomes compared to occiput anterior (OA) positions.
- Conducted at a tertiary hospital, the study analyzed data from 13,852 singleton, vaginal deliveries after 37 weeks from January 2000 to May 2023, finding a significantly higher incidence of complications like assisted deliveries and perineal lacerations in the OP group compared to the OA group.
- Although OP deliveries led to more maternal complications, such as increased labor time and risks of lacerations and hemorrhage, neonatal outcomes remained similar between the two groups.
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