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Enhancing predictive accuracy for urinary tract infections post-pediatric pyeloplasty with explainable AI: an ensemble TabNet approach.
Sci Rep
January 2025
Department of Urology, Capital Institute of Pediatrics, Beijing, China.
Ureteropelvic junction obstruction (UPJO) is a common pediatric condition often treated with pyeloplasty. Despite the surgical intervention, postoperative urinary tract infections (UTIs) occur in over 30% of cases within six months, adversely affecting recovery and increasing both clinical and economic burdens. Current prediction methods for postoperative UTIs rely on empirical judgment and limited clinical parameters, underscoring the need for a robust, multifactorial predictive model.
View Article and Find Full Text PDFInterferon regulatory factor 5 attenuates kidney fibrosis through transcriptional suppression of Tgfbr1.
Int Immunopharmacol
January 2025
Department of Nephrology, State Key Laboratory of Reproductive Medicine, Children's Hospital of Nanjing Medical University, Nanjing 210008 China; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing 210008 China; Jiangsu Key Laboratory of Early Development and Chronic Diseases Prevention in Children, Nanjing Medical University, Nanjing 210029 China. Electronic address:
Tubulointerstitial fibrosis is a common pathway of the progressive development of chronic kidney diseases (CKD) with different etiologies. The transcription factor interferon regulatory factor 5 (IRF5) can induce anti-type I interferons and proinflammatory cytokine genes and has been implicated as a therapeutic target for various inflammatory and autoimmune diseases. Currently, no experimental evidence has confirmed the role of IRF5 in CKD.
View Article and Find Full Text PDFImpact of hydronephrosis on shockwave lithotripsy outcomes for upper ureteral stones.
Int Urol Nephrol
January 2025
Department of Urology, Başkent University Alanya Application and Research Center, Antalya, Turkey.
Purpose: To investigate the effect of the degree of hydronephrosis on extracorporeal shockwave lithotripsy (SWL) success in patients who underwent SWL due to upper ureteral stones.
Methods: Medical records of 878 patients who underwent SWL were retrospectively reviewed. Patients with isolated unilateral 6-10 mm radiopaque upper ureteral stones above the upper border of the sacroiliac joint were included in the study.
Graphene Quantum Dots as Antifibrotic Therapy for Kidney Disease.
ACS Appl Bio Mater
January 2025
Department of Internal Medicine, College of Medicine, Seoul National University, Seoul 03080, Korea.
Graphene quantum dots (GQDs) have received much attention for their biomedical applications, such as bioimaging and drug delivery. Additionally, they have antioxidant and anti-inflammatory properties. We used GQDs to treat renal fibrosis and confirmed their ability to protect renal cells from excessive oxidative stress in vitro and in vivo.
View Article and Find Full Text PDFHydronephrosis and survival in cervical cancer patients: The role of urinary diversion.
Gynecol Oncol Rep
February 2025
Urology Department, Instituto Mexicano del Seguro Social, Unidad de Medicina de Alta Especialidad N° 25, Monterrey, Nuevo León, Mexico.
Objective: We aimed to assess the impact of urinary diversion on survival in patients with advanced cervical cancer (CC) and hydronephrosis. Additionally, we examined the influence of other patient factors and urinary diversion type on survival.
Methods: A retrospective study analyzed survival in cervical cancer (CC) patients with hydronephrosis treated at two Mexican hospitals from 2011 to 2023.
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