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Benign Biphasic Tumors of the Mullerian Tract - a Mimic of Phyllodes Tumor. A Clinical-Pathologic Description of 21 Cases.
Ann Clin Lab Sci
July 2023
Department of Pathology, Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI, USA.
Objective: A review of the clinical-pathologic characteristics and outcomes of biphasic polyps occurring in the female genital tract, not meeting the diagnostic criteria of Mullerian Adenosarcoma (MA).
Methods: An archival database search was run, after IRB approval, between 2001 and 2019, using terminology such as "Mullerian adenofibroma," "atypical Mullerian adenofibroma," "polypoid adenofibroma," and "atypical polyp with increased stromal cellularity." Two pathologists (JW and MRQ) reviewed all the retrieved cases and documented the morphologic features with particular emphasis on the presence of any features of Mullerian adenosarcoma.
Structure-guided identification of potent inhibitors of ROS1 kinase for therapeutic development against non-small cell lung cancer.
J Biomol Struct Dyn
May 2024
Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates.
Article Synopsis
- Proto-oncogene tyrosine-protein kinase ROS (ROS1) is linked to various cancers and is a potential target for anticancer drugs.
- The study conducted a virtual screening of phytochemicals to find inhibitors for ROS1, identifying Helioscopinolide C and Taiwanin C as promising candidates.
- These findings suggest these compounds could be developed into therapies for ROS1-related cancers, particularly non-small cell lung cancer, but further experimental validation is necessary.
Article Synopsis
- SEC14L1 is a gene linked to the movement of fat-soluble vitamins and was found to be significantly associated with lymphovascular invasion (LVI) in a large group of breast cancer patients.
- In a study of 111 different gynecologic tumors, LVI occurred in 28% of cases, with the highest rates seen in uterine carcinosarcoma and high-grade serous carcinoma.
- SEC14L1 was expressed in 23% of the tumors studied, with uterine serous carcinoma showing a notable positive rate, highlighting its potential connection to human epidermal growth factor receptor 2 and suggesting the need for further research.
Italian consensus conference on management of uterine sarcomas on behalf of S.I.G.O. (Societa' italiana di Ginecologia E Ostetricia).
Eur J Cancer
November 2020
Fondazione Policlinico Universitario A. Gemelli IRCCS, Gynecologic Oncology Unit, Roma, Italy; Universita' Cattolica Del Sacro Cuore, Roma, Italy.
Background: Uterine sarcomas are very rare tumours with different histotypes, molecular features and clinical outcomes; therefore, it is difficult to carry out prospective clinical trials, and this often results in heterogeneous management of patients in the clinical practice.
Aim: We planned to set up an Italian consensus conference on these diseases in order to provide recommendations on treatments and quality of care in our country.
Results: Early-stage uterine sarcomas are managed by hysterectomy + bilateral salpingo-oophorectomy according to menopausal status and histology; lymphadenectomy is not indicated in patients without bulky nodes, and morcellation must be avoided.
Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association.
Pathol Res Pract
May 2019
Department of Woman and Child Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Department of Woman and Child Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy - Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address:
It is well known that a large number of patients treated with Tamoxifen develops endometrial pathologies ranging from benign endometrial polyps and hyperplasia to adenocarcinomas, carcinosarcomas and adenosarcomas. UTROSCT (Uterine Tumor Resembling Ovarian Sex Cord Tumor) is defined as a mesenchymal tumors of the uterine corpus that morphologically resembles ovarian sex cord tumors, without recognizable endometrial stroma. To date only 4 cases have been reported in patients treated with tamoxifen.
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