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Viruses and psychiatric disorders: We have not crossed the borderline from hypothesis to proof yet (Review).
Mol Med Rep
March 2025
2nd Department of Psychiatry, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece.
Most psychiatric disorders are heterogeneous and are attributed to the synergistic action of a multitude of factors. It is generally accepted that psychiatric disorders are the outcome of interactions between genetic predisposition and environmental perturbations, which involve psychosocial stress, or alterations in the physiological state of the organism. A number of hypotheses have been presented on such environmental influences that may include direct insults such as injury, malnutrition and hostile living conditions, or indirect sequelae following infection from viruses such as influenza, arboviruses, enteroviruses and several herpesviruses, or the differential expression of human endogenous retroviruses.
View Article and Find Full Text PDFClinical presentation and molecular diagnosis of a possible Mpox virus and Varicella zoster virus co-infection in an adult immunocompetent Filipino: a case report.
Front Public Health
December 2024
Research Institute for Tropical Medicine, Muntinlupa, Philippines.
We report the first travel-related case of a possible Mpox-Varicella zoster virus (VZV) co-infection in the Philippines, a country that is endemic for Varicella but non-endemic for Mpox. A 29-year-old Filipino, female, with a travel history to Switzerland and with no prior history of VZV infection sought consultation due to rashes. She presented with multiple papular, pustular, and vesicular skin lesions, some with umbilication and with irregular borders, on the face, neck, trunk, inguinal area, upper extremities, and right leg.
View Article and Find Full Text PDFMechanisms of HSV gene regulation during latency and reactivation.
Virology
January 2025
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Electronic address:
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are prevalent human pathogens associated with many diseases. After productive (lytic) infection in peripheral tissues, HSV establishes lifelong latent infection in neurons of the peripheral nervous system. Periodic reactivation from latency, triggered by certain stimuli, can resume the lytic cycle.
View Article and Find Full Text PDFSurvey of Post-Prophylaxis Delayed-Onset Cytomegalovirus Management Strategies Among Transplant Providers.
Clin Transplant
November 2024
Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Background: Preventive strategies for cytomegalovirus (CMV) in the posttransplant period have changed the pattern of CMV infections, now more commonly manifesting as late-onset occurrences known as post-prophylaxis delayed-onset CMV disease (PPDOC). We conducted a survey to investigate provider practices in managing PPDOC.
Methods: A web-based provider survey on the management of PPDOC was developed using Research Electronic Data Capture (REDCap).
Detection of anti-EBV TCR CDR3s associated with better outcomes for EBV-positive, Ugandan cases of Burkitt lymphoma.
Int J Cancer
February 2025
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Article Synopsis
- * A study analyzing T-cell receptor (TCR) sequences from EBV-positive Ugandan BL tumors found that the presence of anti-EBV TCR sequences is associated with better survival rates for patients.
- * The findings suggest that targeting EBV in immunotherapy could potentially improve outcomes for patients with Burkitt lymphoma.
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