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Screening a 681-membered yeast collection for the secretion of proteins with antifungal activity.
N Biotechnol
January 2025
Department for Molecular Microbiology, University of Groningen, Nijenborgh 7, 9747 AG Groningen, the Netherlands; Department of Bioengineering, Imperial College London, South Kensington Campus, SSW7 2AZ, London, UK. Electronic address:
Fungal pathogens pose a threat to human health and food security. Few antifungals are available and resistance to all has been reported. Novel strategies to control plant and human pathogens as well as food spoilers are urgently required.
View Article and Find Full Text PDFDesign Strategy of PepNzymes-SH for an Emerging Catalyst with Serine Hydrolase-Like Functionality.
ACS Appl Mater Interfaces
January 2025
CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
Serine hydrolases, as a class of green catalysts with hydrolytic and dehydrating activities, hold significant application value in the fields of biosynthesis and organic synthesis. However, practical applications face numerous challenges, including maintaining enzyme stability and managing usage costs. PepNzymes-SH, an emerging green catalytic material with enzyme-like activity, overcomes the operational limitations of natural enzymes and holds great promise as a substitute for hydrolases.
View Article and Find Full Text PDFStructural analysis of human ADAR2-RNA complexes by X-ray crystallography.
Methods Enzymol
January 2025
Department of Chemistry, University of California, Davis, CA, United States; Department of Molecular and Cellular Biology, University of California, Davis, CA, United States. Electronic address:
Adenosine deaminases acting on RNAs (ADARs) are a class of RNA editing enzymes found in metazoa that catalyze the hydrolytic deamination of adenosine to inosine in duplexed RNA. Inosine is a nucleotide that can base pair with cytidine, therefore, inosine is interpreted by cellular processes as guanosine. ADARs are functionally important in RNA recoding events, RNA structure modulation, innate immunity, and can be harnessed for therapeutically-driven base editing to treat genetic disorders.
View Article and Find Full Text PDFEvaluating the Role of Viable Cells, Heat-Killed Cells or Cell-Free Supernatants in Bacterial Biocontrol of Fungi: A Comparison Between Lactic Acid Bacteria and .
Microorganisms
January 2025
Department of Food Science and Technologies for Sustainable Agro-Food Chain (DiSTAS), Università Cattolica del Sacro Cuore, 29122 Piacenza, PC, Italy.
This study investigated whether viable cells, dead cells or cell-free supernatants (CFS) were responsible for the biocontrol effect of strains from two important bacterial genera, and , known for their antifungal properties against plant pathogens and food spoilage microorganisms. Specifically, the capability of these strains to produce extracellular hydrolytic enzymes on specified media was assessed, along with their effectiveness in inhibiting the mycelial growth of several phytopathogenic fungi (, , and ) using dual culture plate assays. Results from these inhibition assays revealed that PF05 and LMG 23520 strains were the most effective in suppressing fungal growth, especially .
View Article and Find Full Text PDFADAR Therapeutics as a New Tool for Personalized Medicine.
Genes (Basel)
January 2025
Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
In the field of RNA therapy, innovative approaches based on adenosine deaminases acting on RNA (ADAR)-mediated site-directed RNA editing (SDRE) have been established, providing an exciting opportunity for RNA therapeutics. ADAR1 and ADAR2 enzymes are accountable for the predominant form of RNA editing in humans, which involves the hydrolytic deamination of adenosine (A) to inosine (I). This inosine is subsequently interpreted as guanosine (G) by the translational and splicing machinery because of their structural similarity.
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