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Phenotypic upregulation of hexocylceramides and ether-linked phosphocholines as markers of human extreme longevity.
Aging Cell
December 2024
Department of Experimental Medicine, University of Lleida-Lleida Biomedical Research Institute (UdL-IRBLleida), Lleida, Spain.
Centenarians and their relatives possess a notable survival advantage, with higher longevity and reduced susceptibility to major age-related diseases. To date, characteristic omics profiles of centenarians have been described, demonstrating that these individuals with exceptional longevity regulate their metabolism to adapt and incorporate more resilient biomolecules into their cells. Among these adaptations, the lipidomic profile stands out.
View Article and Find Full Text PDFSelective Enrichment via TiO Magnetic Nanoparticles Enables Deep Profiling of Circulating Neutral Glycosphingolipids.
Anal Chem
October 2024
MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China.
Circulating neutral glycosphingolipids (neutral GSLs (nGSLs)) are a unique subset of nGSLs that detach from organs or cell membranes and enter the bloodstream. Altered molecular distribution of circulating nGSL is increasingly associated with diseases. However, profiling of circulating nGSLs presents a lasting challenge due to their low abundances and structural complexity.
View Article and Find Full Text PDFGAL3ST1 Deficiency Reduces Epithelial-Mesenchymal Transition and Tumorigenic Capacity in a Cholangiocarcinoma Cell Line.
Int J Mol Sci
July 2024
Department of Surgery, School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.
Cholangiocarcinoma (CCA), or bile duct cancer, is the second most common liver malignancy, with an increasing incidence in Western countries. The lack of effective treatments associated with the absence of early symptoms highlights the need to search for new therapeutic targets for CCA. Sulfatides (STs), a type of sulfoglycosphingolipids, have been found in the biliary tract, with increased levels in CCA and other types of cancer.
View Article and Find Full Text PDFInvestigation of Clinical Features and Association between Vascular Endothelial Injury Markers and Cytomegalovirus Infection Associated with Thrombotic Microangiopathy in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: Case-Based Research.
Int J Mol Sci
January 2024
Department of Nephrology, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto 390-8621, Japan.
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) can occasionally trigger thrombotic microangiopathy (TMA). Cytomegalovirus (CMV) may be reactivated during intensive immunosuppressive therapy for AAV and cause TMA. Therefore, we aimed to evaluate the clinical features of and the association between vascular endothelial injury markers and TMA due to CMV in patients with AAV.
View Article and Find Full Text PDFThe structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family.
Nat Commun
September 2023
Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Article Synopsis
- - Tryptophan Rich Antigens (TRAgs) are a group of proteins found in all Plasmodium species, but they're especially abundant in P. vivax and related parasites, and they play a role in the invasion of red blood cells.
- - Scientists discovered that the TRAg PVP01_0000100 binds to reticulocytes through its C-terminal tryptophan-rich domain, which was structurally analyzed using X-ray crystallography and found to resemble lipid-binding domains.
- - The study shows that PVP01_0000100 has a preference for binding sulfatide, a lipid found in cell membranes, and that its equivalent in P. knowlesi is crucial for the parasite
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