Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
An Outbreak of Foodborne Botulism Caused by BoNT/A3 in Pickled Eggs - Weihai City, Shandong Province, China, July 2024.
China CDC Wkly
December 2024
Weihai Center for Disease Control and Prevention, Weihai City, Shandong Province, China.
What Is Already Known About This Topic?: Foodborne botulism is caused by botulinum neurotoxin (BoNT). () is a strictly anaerobic, Gram-positive bacterium, which is a key pathogen capable of producing BoNT. BoNTs can be classified into seven serotypes (A to G) based on their antigenic properties.
View Article and Find Full Text PDFPassive Immunisation in the Treatment of Infectious Diseases Related to Highly Potent Bacterial Toxins.
Biomedicines
December 2024
National Institute of Public Health NIH-National Research Institute, Chocimska 24, 00-791 Warsaw, Poland.
The discovery of microbial toxins as the primary factors responsible for disease manifestations and the discovery that these toxins could be neutralised by antitoxins are linked to the birth of immunology. In the late 19th century, the serum or plasma of animals or patients who had recovered from infectious diseases or who had been immunised with a relevant antigen began to be used to treat or prevent infections. Before the advent of widespread vaccination campaigns, antitoxins played a key role in the treatment and prevention of diseases such as diphtheria and tetanus.
View Article and Find Full Text PDFDevelopment and selection of candidate monoclonal antibodies for the detection of Clostridium botulinum neurotoxin serotype B light chain.
Protein Expr Purif
April 2025
Institute of Tropical Medicine, Joint Vietnam-Russia Tropical Science and Technology Research Center, Viet Nam.
Botulinum neurotoxin, produced by the bacterium Clostridium botulinum, causes botulism, a severe, rapidly progressing, and potentially fatal condition. Swift detection of the toxin and timely administration of antitoxin antibodies are critical for effective treatment. The current standard for Botulinum toxin testing is the mouse lethality assay, but this method is time-consuming and requires live animals.
View Article and Find Full Text PDF[Infant botulism: an underestimated problem. A review].
Ter Arkh
December 2024
Izhevsk State Medical Academy.
The article is devoted to a form of botulism that has been little studied in our country and is registered exclusively in infants. The fundamental difference between this form and the most common foodborne botulism is that infants become infected by ingestion of spores, followed by their germination, colonization of the intestines and production of botulinum toxin , which leads to the development of life-threatening flaccid paralysis. Taking into account the peculiarities of pathogenesis, the clinical manifestations of infant botulism have some features, which are discussed by the authors.
View Article and Find Full Text PDFIatrogenic Botulism Following Botulinum Toxin Injection as an Adjunct to Abdominal Wall Reconstruction for Incisional Hernia.
Cureus
November 2024
General Surgery, Hospital Professor Doutor Fernando Fonseca, Amadora, PRT.
Open ventral hernia repair is one of the most commonly performed surgeries by general surgeons worldwide. In the case of complex incisional hernias, there are adjunct techniques that can help abdominal wall reconstruction surgery, such as type A botulinum toxin (BTA), whose injection results in muscle relaxation and growth of muscle fiber length, allowing fascial closure without the need for advanced techniques. We report a case of a male patient who underwent ultrasound-guided BTA injection in the abdominal wall and, five days later, was admitted to our emergency department with dysarthria, muscular weakness, dyspnea on small exertion, and constipation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!