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Viperin Targets Flavivirus Virulence by Inducing Assembly of Noninfectious Capsid Particles.
J Virol
January 2018
Department of Clinical Microbiology, Virology, Umeå University, Umeå, Sweden
Efficient antiviral immunity requires interference with virus replication at multiple layers targeting diverse steps in the viral life cycle. We describe here a novel flavivirus inhibition mechanism that results in interferon-mediated obstruction of tick-borne encephalitis virus particle assembly and involves release of malfunctioning membrane-associated capsid (C) particles. This mechanism is controlled by the activity of the interferon-induced protein viperin, a broad-spectrum antiviral interferon-stimulated gene.
View Article and Find Full Text PDFBeta cell expression of endogenous xenotropic retrovirus distinguishes diabetes-susceptible NOD/Lt from resistant NON/Lt mice.
J Clin Invest
December 1992
Jackson Laboratory, Bar Harbor, Maine 04609.
Endogeneous retroviral expression in beta cells is a feature of prediabetes in nonobese diabetic (NOD) mice. The purpose of this study was to characterize the class-specific pattern of retroviral gene expression in NOD/Lt beta cells versus a related, but diabetes-resistant strain, NON/Lt. Electron microscopic comparison of beta cells from both strains indicated low constitutive expression of the intracisternal type A (IAP) retroviral class.
View Article and Find Full Text PDF[Electron microscopic observation of ATLV (adult T-cell leukemia associated virus)].
Gan To Kagaku Ryoho
February 1983
The morphological structure and morphogenesis of ATLV produced from MT-1, MT-2 cell lines and short-term cultured cells from peripheral lymphocytes of ATL patients were observed by electronmicroscopy. The average diameter of ATLV particles was approximately 110 nm, and the distribution curve of diameter was wide. The ATLV was produced by budding process but budding was very rare.
View Article and Find Full Text PDFCell-mediated immune response to simian oncornavirus antigens in pregnant women.
J Natl Cancer Inst
March 1978
Tritiated thymidine incorporation into lymphocytes of 118 adult women was studied in the presence of mitomycin C-treated cells prepared from cell lines continuously producing Mason-Pfizer monkey virus (MPMV), baboon C-particle virus, or simian sarcoma virus (SSV) and in the presence of control cell lines documented for the absence of oncornaviruses. At the end of pregnancy, women who had 5-9 pregnancies showed a high frequency (53%) of specific positive responses to cells with MPMV antigens. The frequencies were 15% for pregnant women with smaller numbers of pregnancies and 3% for nonpregnant women with similar numbers of previous pregnancies as in the pregnancy group.
View Article and Find Full Text PDFEighty newborn C3H/BifB/Ki strain mice received a single intraocular inoculation of 0.002--0.003 ml of 10(8.
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