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The diversion tunnel is frequently subjected to cyclic dynamic loads during blasting and mechanical excavation. To explore the theory and mechanism of cyclic dynamic mechanical damage for granite in a diversion tunnel under cyclic loading-unloading, the incremental cyclic loading-unloading test and numerical simulation were conducted on granite samples from the diversion tunnel. According to the mechanical and deformation characteristics of rock samples in the process of cyclic loading-unloading, the stress-strain normalization theory evolution model based on viscoelastoplasticity was established, and the cyclic dynamic damage evolution mechanism of rock samples was revealed.

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This study investigates the synergistic inhibitory effects of combining the stimulator of interferon genes (STING) agonist cyclic diadenylate monophosphate (c-di-AMP) and ginsenoside RG3 on cisplatin (DDP)-resistant gastric cancer (GC) cells. The objective is to identify novel therapeutic targets and offers insights for the clinical management of DDP resistance. Various techniques were employed, including western blot, MTT assay, colony formation assay, scratch assay, transwell assay, tubule formation assay, flow cytometry, Hoechst 33342 fluorescence staining, and in vivo experiments, to investigate the potential mechanisms and effects of the combined application of the STING agonist and ginsenoside RG3 in reversing cisplatin resistance in gastric cancer.

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Background: Spinal cord injury (SCI) treatment remains a formidable challenge, as current therapeutic approaches provide only marginal relief and fail to reverse the underlying tissue damage. This study aims to develop a novel composite material combining enzymatic nanoparticles and nerve growth factor (NGF) to modulate the immune microenvironment and enhance SCI repair.

Methods: CeMn nanoparticles (NP) and CeMn NP-polyethylene glycol (PEG) nanozymes were synthesized via sol-gel reaction and DSPE-mPEG modification.

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Acetylcholine modulates the network physiology of the hippocampus, a crucial brain structure that supports cognition and memory formation in mammals . In this and adjacent regions, synchronized neuronal activity within theta-band oscillations (4-10Hz) is correlated with attentive processing that leads to successful memory encoding . Acetylcholine facilitates the hippocampus entering a theta oscillatory regime and modulates the temporal organization of activity within theta oscillations .

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This study investigates solute-solvent interactions in ternary systems consisting of lithium trifluoromethanesulfonate (LiOTf) as the solute and tetraethylene glycol dimethyl ether (TEGDME) and 1,2-dimethoxyethane (DME) as solvents over a range of temperatures (293.15-313.15 K).

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