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Distribution of airway pressure opening in the lungs measured with electrical impedance tomography (POET): a prospective physiological study.
Crit Care
January 2025
Keenan Centre for Biomedical Research, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, ON, Canada.
Background: In patients with acute hypoxemic respiratory failure (AHRF) under mechanical ventilation, the change in pressure slope during a low-flow insufflation indicates a global airway opening pressure (AOP) needed to reopen closed airways and may be used for titration of positive end-expiratory pressure.
Objectives: To understand 1) if airways open homogeneously inside the lungs or significant regional AOP variations exist; 2) whether the pattern of the pressure slope change during low-flow insufflation can indicate the presence of regional AOP variations.
Methods: Using electrical impedance tomography, we recorded low-flow insufflation maneuvers (< 10 L/min) starting from end-expiratory positive pressure 0-5 cmHO.
Comprehensive industry-relevant black soldier fly bioconversion characterisation by a novel chamber system.
Waste Manag
December 2024
ETH Zurich, Laboratory of Sustainable Food Processing, Schmelzbergstrasse 9 8092, Zurich, Switzerland; Singapore-ETH Centre,1 Create Way 138602, Singapore.
Black soldier fly larvae (BSFL) efficiently convert biowaste into valuable animal feed. Sustainable and reliable bioconversion is desirable to achieve optimal economic and environmental outcomes. Thus, science and industry require an accessible research platform to study complex bioconversion processes under conditions mirroring industrial-scale settings.
View Article and Find Full Text PDFSelective metabolic regulations by p53 mutant variants in pancreatic cancer.
J Exp Clin Cancer Res
November 2024
Chair for Systems Toxicology, Department of Biology, University of Konstanz, Konstanz, Germany.
Background: Approximately half of all human cancers harbour mutations in the p53 gene, leading to the generation of neomorphic p53 mutant proteins. These mutants can exert gain-of-function (GOF) effects, potentially promoting tumour progression. However, the clinical significance of p53 GOF mutations, as well as the selectivity of individual variants, remains controversial and unclear.
View Article and Find Full Text PDFEsophageal pressure as estimation of pleural pressure: a study in a model of eviscerated chest.
BMC Anesthesiol
November 2024
Dipartimento Area Emergenza Urgenza, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Background: Transpulmonary pressure is the effective pressure across the lung parenchyma and has been proposed as a guide for mechanical ventilation. The pleural pressure is challenging to directly measure in clinical setting and esophageal manometry using esophageal balloon catheters was suggested for estimation. However, the accuracy of using esophageal pressure to estimate pleural pressure is debated due to variability in the mechanical properties of respiratory system, esophagus and esophageal catheter.
View Article and Find Full Text PDFEffect of alternative oxidase (AOX) expression on mouse cerebral mitochondria bioenergetics.
Redox Biol
November 2024
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY, 10065, USA. Electronic address:
Alternative oxidase (AOX) is an enzyme that transfers electrons from reduced quinone directly to oxygen without proton translocation. When AOX from Ciona intestinalis is xenotopically expressed in mice, it can substitute the combined electron-transferring activity of mitochondrial complexes III/IV. Here, we used brain mitochondria from AOX-expressing mice with such a chimeric respiratory chain to study respiratory control bioenergetic mechanisms.
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