AI Article Synopsis
- Extracts from canine liver were found to inhibit the growth of the infectious canine hepatitis virus (ICH), which is a type of adenovirus.
- The study showed that only mammalian liver extracts, and not those from birds, contained the inhibitory factor, identified as the enzyme arginase.
- This research highlights the importance of arginine for the growth of adenoviruses and sheds light on challenges in isolating small quantities of ICH virus from liver suspensions.
Article Abstract
Extracts of canine liver inhibited growth of infectious canine hepatitis (ICH) virus, a canine adenovirus. Purified extracts from mammalian, but not avian, liver tissue contained the inhibitor, and evidence is presented that the inhibitory factor is the enzyme arginase (arginine ureohydrolase). This study further emphasized the need for arginine in adenovirus growth and may explain some of the difficulties in isolating small amounts of ICH virus from suspensions of liver.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC422540 | PMC |
| http://dx.doi.org/10.1128/iai.6.3.348-354.1972 | DOI Listing |
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