Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The current landscape of 1,2,3-triazole hybrids with anticancer therapeutic potential: Part I.
Arch Pharm (Weinheim)
March 2025
School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, China.
Cancer, with its steadily increasing morbidity and mortality, will continue to pose a threat to humanity over an extended period. Chemotherapeutics play an indispensable role in cancer treatment, and hundreds of drugs have been approved for this purpose. Nevertheless, the fight against cancer remains a formidable challenge.
View Article and Find Full Text PDFBta-miR-93 regulates the maternal-fetal tolerance in dairy cows via promoting PD-L1-mediated M2 macrophage polarization†.
Biol Reprod
March 2025
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, People's Republic of China.
Bovine embryo resorption is one of the key factors restricting the reproductive efficiency in dairy cattle, which mainly occurs in the early stage of maternal recognition of pregnancy (MRP), causing substantial economic losses to the dairy industry. Macrophages, the most numerous endometrial immune cells in cows during early pregnancy, are critical in developing maternal-fetal immune tolerance. However, the mechanism of their action on the maternal-fetal interface of dairy cows remains unknown.
View Article and Find Full Text PDFPhytochemical, In Silico, In Vitro, and In Vivo Research on Piptadeniastrum africanum (Fabaceae) Unveiling Anti-Stereotypic, Anxiolytic, and Analgesic Effects in a Sodium Valproate-Induced Autistic Disorders Model.
Brain Behav
March 2025
Department of Animal Biology and Physiology, Laboratory of Animal Physiology, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
Objective: Individuals with autistic spectrum disorders (ASD) primarily exhibit deficits in communication and social interaction, along with repetitive behaviors and restricted interests. This disorder is often associated with anxiety, nociceptive disorders, and pain. While medical treatment generally focuses on treating the symptoms rather than addressing the underlying causes, traditional medicine is sometimes used as an alternative.
View Article and Find Full Text PDFNecroptotic Suppression of Lung Cancer Cell Proliferation and Migration: A Comprehensive In Vitro and In Silico Study to Determine New Molecular Targets for Pexidartinib.
Cell Biochem Funct
March 2025
Department of Biophysics, School of Medicine, Koç University, Sarıyer, Istanbul, Türkiye.
In this study, the cytotoxic effects of pexidartinib (PLX), a tyrosine kinase inhibitor approved for tenosynovial giant cell tumor through inhibition of colony-stimulating factor 1 receptor (CSF1R), against A549 lung adenocarcinoma cells and Beas-2B healthy bronchial cells were investigated by in detailed in-vitro and in-silico studies. Through MTT assays, PLX demonstrated significant inhibition of A549 cell viability with IC values of 2.15 and 1.
View Article and Find Full Text PDFDesign, synthesis, and biological evaluation of novel derivatives of marine natural product ammosamide B.
Pest Manag Sci
March 2025
Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, China.
Background: Plant diseases caused by plant viruses and pathogens seriously affect crop yield and quality, making prevention and control extremely difficult and posing a serious threat to human health. Marine alkaloids have novel structures and diverse biological activities, which are an important source of the development of new pesticides. In this work, ammosamide alkaloids were selected as the parent structure.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!