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Gut microbiome-driven regulation of sex hormone homeostasis: a potential neuroendocrine connection.
Gut Microbes
December 2025
Department of Nutrition Science, Purdue University, West Lafayette, IN, USA.
The gut microbiome is known to have a bidirectional relationship with sex hormone homeostasis; however, its role in mediating interactions between the primary regulatory axes of sex hormones and their productions is yet to be fully understood. We utilized both conventionally raised and gnotobiotic mouse models to investigate the regulatory role of the gut microbiome on the hypothalamic-pituitary-gonadal (HPG) axis. Male and female conventionally raised mice underwent surgical modifications as follows: (1) hormonally intact controls; (2) gonadectomized males and females; (3) gonadectomized males and females supplemented with testosterone and estrogen, respectively.
View Article and Find Full Text PDFAmeliorative effect of Fagonia indica-coated chitosan nanoparticles on the ovulatory pattern in PCOS rat model.
J Ovarian Res
March 2025
Physiology and Toxicology Laboratory, Department of Zoology, Government College University Lahore, Lahore, Pakistan.
Background: Polycystic ovarian syndrome (PCOS) with wide-range prevalence, affecting 5-18% of females of reproductive age, and its substantive role as a primary etiological factor in anovulatory infertility, with up to 80% of such cases attributed to this syndrome having particular significance.
Objectives: The current research delineates the outcomes of a meticulous inquiry into the efficacy of Fagonia indica-coated chitosan nanoparticles (FICNPs) in ameliorating the prevalent and clinically consequential PCOS in female Wistar rats.
Methodology: FICNPs were synthesized by using a methanolic extract of F.
Systematic review and meta-analysis of animal experiments on Bushen formulas for the treatment of polycystic ovary syndrome.
Sci Rep
March 2025
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.
The treatment of polycystic ovary syndrome (PCOS) with Bushen traditional Chinese medicine has a long history. Every year, there are animal experiments on Bushen formulas for the treatment of PCOS. The evidence from these preclinical studies is still unclear.
View Article and Find Full Text PDFThe correlation between serum sex hormone levels and clear cell renal cell carcinoma in male patients.
Sci Rep
March 2025
Department of Urology, Ruijin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China.
To investigate the correlation between serum sex hormone levels and clear cell renal cell carcinoma(ccRCC). The clinical data of male patients diagnosed with ccRCC and with simple renal cysts in our hospital from 2017 to 2023 were collected. The basic clinical data and serum sex hormone levels, including luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol(E), prolactin (PRL), progesterone(P), and testosterone (T), were compared between patients with ccRCC and patients with simple renal cysts.
View Article and Find Full Text PDFThree types of 17β-hydroxysteroid dehydrogenases involved in Japanese eel ovarian steroidogenesis.
Gen Comp Endocrinol
February 2025
Fisheries Technology Institute, Minamiizu Field Station, Japan Fisheries Research and Education Agency, Minamiizu, Kamo, Shizuoka 415-0156, Japan. Electronic address:
The synthesis of estradiol-17β (E2), an important steroid hormone in piscine gametogenesis, is catalyzed by various steroidogenic enzymes under the control of pituitary gonadotropins (Gths), follicle-stimulating hormone (Fsh), and luteinizing hormone (Lh). Among these enzymes, 17β-hydroxysteroid dehydrogenases (Hsd17bs) with 17β-hydroxysteroid dehydrogenase/17-ketosteroid reductase activities are crucial enzymes in the synthesis of sex steroid hormones in gonadal and extra-gonadal tissues. In teleost species, although Hsd17b1 is recognized as essential for E2 synthesis, other Hsd17b types have recently been shown to have the potential to produce E2; however, information is limited.
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