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Clusterin Deficiency Promotes Cellular Senescence in Human Astrocytes.
Mol Neurobiol
December 2024
Department of Physiology, Faculty of Science, Charles University, Prague, 128 00, Czech Republic.
Article Synopsis
- - The study focuses on the glycoprotein clusterin (CLU), which is important for cell growth and repairing DNA, and its effects on human astrocytic cell lines, showing that suppressing CLU leads to decreased cell growth and increased DNA damage response.
- - Researchers found that reducing CLU levels caused oxidative stress and triggered cellular aging (senescence) in astrocytoma cells and normal astrocytes, impacting mitochondrial function and altering energy production markers.
- - The findings highlight the crucial role of CLU in maintaining the cell cycle in astrocytes, suggesting that targeting CLU could be a promising strategy for treating gliomas (a type of brain tumor).
BK Virus Nephropathy After Kidney Transplantation and Its Diagnosis Using Urinary Micro RNA.
Transplant Proc
November 2024
Department of Surgery Nephrology Center, Toranomon Hospital, Tokyo Japan.
BK virus-associated nephritis (BKVAN) is an important cause of graft loss in renal transplant recipients B K viremia occurs in up to 30% of renal transplant recipients. Since the discovery of BKV in 1971, effective prophylaxis and treatment have not been established, and it is not uncommon for a transplant kidney to be lost without cure of BKVAN. BK virus infection is reactivated when cellular immunity is suppressed, which is often during the first year after kidney transplantation when cellular immunity is most suppressed.
View Article and Find Full Text PDFReticulophagy and viral infection.
Autophagy
January 2025
Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
Article Synopsis
- All viruses rely on the host's cellular machinery to produce their proteins, specifically utilizing the endoplasmic reticulum (ER) in eukaryotic cells for this process.
- Viruses can manipulate the ER to create structures for viral production while avoiding detection by the host's immune system.
- Reticulophagy, a process that degrades ER components, acts as an antiviral defense mechanism (termed "xERophagy"), but viruses have also evolved ways to counteract this defense to enhance their replication.
Rutaecarpine alleviates inflammation and fibrosis by targeting CK2α in diabetic nephropathy.
Biomed Pharmacother
November 2024
Department of Nephropathy, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, PR China. Electronic address:
Diabetic nephropathy (DN) is one of the serious microvascular complications of diabetes mellitus. During the progression of DN, the proliferation of glomerular mesangial cells (GMCs) leads to the deposition of excessive extracellular matrix (ECM) in the mesangial region, eventually resulting in glomerulosclerosis. Rutaecarpine (Rut), an alkaloid found in the traditional Chinese medicinal herb Fructus Evodiae (Euodia rutaecarpa (Juss.
View Article and Find Full Text PDFAstragaloside I from Attenuates Diabetic Kidney Disease by Regulating HDAC3/Klotho/TGF-1 Loop.
Am J Chin Med
November 2024
Henan Collaborative Innovation Center for Research and Development on the Whole Industry, Chain of Yu-Yao, Henan University of Chinese Medicine, No. 156, Jinshui East Road, Zhengzhou, 450046, P.R. China.
Diabetic kidney disease (DKD) has become the primary cause of end-stage renal disease (ESRD), causing an urgent need for preventive strategies for DKD. Astragaloside I (ASI), a bioactive saponin extracted from (Fisch.) Bunge has been demonstrated to possess a variety of biological activities.
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