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Larviciding for malaria control and elimination in Africa.
Malar J
January 2025
RBM Partnership Vector Control Working Group, Chem du Pommier 40, 1218, Le Grand-Saconnex, Switzerland.
Background: Global progress toward malaria elimination and eradication goals has stagnated in recent years, with many African countries reporting increases in malaria morbidity and mortality. Insecticide-treated nets and indoor residual spraying are effective, but the emergence and increased intensity of insecticide resistance and the challenge of outdoor transmission are undermining their impact. New tools are needed to get back on track towards global targets.
View Article and Find Full Text PDFOptical Fresnel zone plate flat lenses made entirely of colored photoresist through an i-line stepper.
Light Sci Appl
January 2025
Institute for Photon Science and Technology, The University of Tokyo, Tokyo, Japan.
Light manipulation and control are essential in various contemporary technologies, and as these technologies evolve, the demand for miniaturized optical components increases. Planar-lens technologies, such as metasurfaces and diffractive optical elements, have gained attention in recent years for their potential to dramatically reduce the thickness of traditional refractive optical systems. However, their fabrication, particularly for visible wavelengths, involves complex and costly processes, such as high-resolution lithography and dry-etching, which has limited their availability.
View Article and Find Full Text PDFDeep eutectic solvent enhances antibacterial activity of a modular lytic enzyme against Acinetobacter baumannii.
Sci Rep
January 2025
Laboratory of Extremophiles Biology, Department of Microbiology, Faculty of Biology, University of Gdansk, Wita Stwosza 59, Gdansk, 80-308, Poland.
In this study, we evaluated the combined effect between MLE-15, a modular lytic enzyme composed of four building blocks, and reline, a natural deep eutectic solvent. The bioinformatic analysis allowed us to determine the spatial architecture of MLE-15, whose components were bactericidal peptide cecropin A connected via a flexible linker to the cell wall binding domain (CBD) of mesophilic 201ϕ2 - 1 endolysin and catalytic domain (EAD) of highly thermostable Ph2119 endolysin. The modular enzyme showed high thermostability with the melting temperature of 93.
View Article and Find Full Text PDFAntibody functionalized curcuma-derived extracellular vesicles loaded with doxorubicin overcome therapy-induced senescence and enhance chemotherapy.
J Control Release
January 2025
Department of General Surgery, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110042, China; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China. Electronic address:
Conventional cancer treatments often induce a sustained DNA damage response (DDR) in tumor cells, leading to therapy-induced senescence (TIS), characterized by permanent cell cycle arrest and resistance to apoptosis. These senescent cells secrete senescence-associated secretory phenotypes (SASP), which can promote tumor progression and create an immunosuppressive microenvironment. This study introduces a novel approach to enhance chemotherapy efficacy by using functionalized curcuma-derived extracellular vesicles (DR5-CNV/DOX) to target and eliminate senescent tumor cells and inhibit their SASP.
View Article and Find Full Text PDFOptimizing low-temperature CO oxidation under realistic combustion conditions: The impact of CeO morphology on Au/CeO catalysts.
J Hazard Mater
January 2025
State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, PR China; Suzhou Key Laboratory for Urban Public Safety, Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, Jiangsu 215123, PR China. Electronic address:
The development of carbon monoxide oxidation catalysts for complex gas environments faces significant challenges in fire scenarios. Only a few representative gases are used as interfering components in simulated real smoke under laboratory conditions, which cannot accurately reflect the performance of catalysts in a real fire. Herein, Au/CeO catalysts with high activity were prepared by adjusting the morphology (rod, cube, polyhedron and irregular particles) and exposed crystal surface ratio of CeO.
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