AI Article Synopsis
- The study investigates how human adenovirus fails to replicate in monkey cells and how this issue can be resolved through coinfection with simian virus 40 (SV40).
- It was found that in the absence of SV40, adenovirus capsid proteins are not produced effectively in monkey cells.
- The enhancement of adenovirus replication by SV40 occurs when both viruses infect the same cells, indicating that the replication block happens before the formation of viral particles.
Article Abstract
The defect which prevents human adenovirus replication in monkey cells and the mechanism whereby this restriction is overcome by coinfection with simian virus 40 (SV40) have been studied. Adenovirus capsid proteins are not synthesized efficiently in monkey cells in the absence of SV40. Adenovirus "enhancement" by SV40 was found to be the product of increased efficiency of replication by a small percentage of cells. This enhancement effect apparently occurred only when SV40 and adenovirus infected the same cells. These findings suggest that the replicative block occurs prior to virion assembly, and an accompanying report seeks to locate the site of restriction more precisely at the post-transcriptional level.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC356452 | PMC |
| http://dx.doi.org/10.1128/JVI.10.2.211-219.1972 | DOI Listing |
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