Mutants that require exogenous 3',5'-cyclic adenosine monophosphate (cAMP) for exponential growth were isolated from strains deficient in adenyl cyclase. Studies of one strain showed that cAMP is not incorporated into macromolecules; instead, it seems to have a regulatory function, i.e., in media lacking cAMP, cells form ribonucleic acid (RNA) and protein at linear rather than exponential rates. The exact lesion is not known; ribosomes, messenger RNA, and the beta and beta' subunits of RNA polymerase continue to be made in absence of added cAMP.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC251348 | PMC |
| http://dx.doi.org/10.1128/jb.111.3.745-749.1972 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hunger Games: A Role for cAMP.
Am J Physiol Endocrinol Metab
January 2025
Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela, 15782, Spain.
The established dogma about regulation of feeding is based on the interaction amongst hypothalamic orexigenic and anorexigenic neuropeptides. However, the molecular underpinnings of those interactions remain unclear. A recent article published in by first demonstrated that the transition between hunger and satiety depends on the regulation of 3',5'-cyclic adenosine monophosphate (cAMP) in the paraventricular nucleus of the hypothalamus (PVH) providing novel insights on the spatial and temporal basis by which neuropeptides act.
View Article and Find Full Text PDFDNA Imprinting and Differentially Expressed Genes in Muscle of Submitted to Early Weaning Management.
Epigenomes
December 2024
School of Veterinary and Animal Science (FMVZ), São Paulo State University (Unesp), Botucatu 18618-681, SP, Brazil.
Early weaning management followed by energy supplementation can lead to metabolic alterations in the calf that exert long-term effects on the animal's health and performance. It is believed that the main molecular basis underlying these metabolic adaptations are epigenetic mechanisms that regulate, activate, or silence genes at different stages of development and/or in response to different environmental stimuli. However, little is known about postnatal metabolic programming in .
View Article and Find Full Text PDFG-protein-coupled receptor 41 in cardiomyocytes: Effect of butyrate on intracellular Ca and sarcomere shortening.
FASEB J
December 2024
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
G-protein-coupled receptor 41 (GPR41) is a Gα-coupled receptor activated by short-chain fatty acids (SCFAs). Here, we tested that GPR41 is also expressed in cardiomyocytes and exerts a direct negative inotropic effect when activated by SCFA butyrate. Primary cardiomyocytes were isolated from wild-type (WT) and GPR41 knockout (GPR41) adult mice and intracellular Ca concentration and cell shortening were measured using the IonOptix system.
View Article and Find Full Text PDFInhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.
Sci Adv
December 2024
Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Cyclic nucleotide-dependent phosphodiesterases (PDEs) play essential roles in regulating the malaria parasite life cycle, suggesting that they may be promising antimalarial drug targets. PDE inhibitors are used safely to treat a range of noninfectious human disorders. Here, we report three subseries of fast-acting and potent PDEβ inhibitors that block asexual blood-stage parasite development and that are also active against human clinical isolates.
View Article and Find Full Text PDFSex-dimorphic glucose transporter-2 regulation of cAMP-protein kinase A (PKA) C-alpha pathway activity and phosphorylation in rat hypothalamic primary astrocyte cultures.
Eur J Neurosci
December 2024
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, USA.
Brain astrocyte glycogenolysis is regulated in part by the second messenger adenosine 3'5'-cyclic monophosphate (cAMP). Hypothalamic astrocyte glycogen metabolism shapes glucose counterregulation, under the control of glucose transporter-2 (GLUT2), a plasma membrane glucose carrier and sensor. Hypothalamic astrocyte cAMP is subject to neurotransmitter control, but effects of nutrient cues on this messenger are unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!