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Facts and hopes in neoadjuvant immunotherapy combinations in resectable non-small-cell lung cancer.
Clin Cancer Res
January 2025
University Hospital Essen, Essen, Germany.
Antibodies targeting immune checkpoints, such as PD-1, PD-L1, or CTLA-4, have transformed the treatment of patients with lung cancers. Unprecedented rates of durable responses are achieved in an imperfectly characterized population of patients with metastatic disease. More recently, immune checkpoint inhibitors have been explored in patients with resectable non-small-cell lung cancers.
View Article and Find Full Text PDFBrucella Endocarditis: A Case Series.
Cureus
December 2024
Internal Medicine, Sher-I-Kashmir Institute Of Medical Sciences, Srinagar, IND.
Brucellosis is one of the most common zoonotic infections present worldwide. It usually presents as a febrile illness but can affect multiple organs of the body. Although cardiac involvement in brucellosis is rare, it is a fatal organ involvement.
View Article and Find Full Text PDFEffects of multidomain lifestyle intervention on frailty among older men and women - a secondary analysis of a randomized clinical trial.
Ann Med
December 2025
Department of Public Health, Lifestyles and Living Environments Unit, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Background: Frailty is a common geriatric syndrome associated with poor clinical outcomes. Effectiveness of lifestyle intervention programmes among frail older people has been examined earlier, but effects of interventions on prevention of frailty have been rarely studied. The aim of this study was to investigate to what extent the multidomain lifestyle intervention in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) affected changes in frailty status among older men and women at risk of cognitive disorders.
View Article and Find Full Text PDFHuman Riboviruses: A Comprehensive Study.
J Mol Evol
December 2024
Department of Zoology, Hansraj College, University of Delhi, Mahatma Hansraj Marg, Malkaganj, Delhi, 110007, India.
The urgency to understand the complex interactions between viruses, their animal reservoirs, and human populations has been necessitated by the continuous spread of zoonotic viral diseases as evidenced in epidemics and pandemics throughout human history. Riboviruses are involved in some of the most prevalent human diseases, responsible for causing epidemics and pandemics. These viruses have an animal origin and have been known to cross the inter-species barrier time and time again, eventually infecting human beings.
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