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A natural carboxylated sisal fiber/chitosan/kaolin porous sponge for rapid and effective hemostasis.
Int J Biol Macromol
December 2024
State Key Laboratory Developmental Biology of Freshwater Fish, School Life Science, Hunan Normal University, Changsha 410081, PR China. Electronic address:
Article Synopsis
- The study developed a chitosan-based composite sponge (SF/CS/K) using carboxylated sisal fiber and kaolin to enhance hemostatic properties, employing a freeze-drying method with various weight ratios.
- * The composite sponges exhibited significant qualities like high mechanical strength, porosity, biodegradation, and effective antibacterial activity, making them suitable for medical applications.
- * In tests involving rat models, the SF/CS/K sponge showed superior coagulation and hemostatic effects compared to commercial sponges, indicating its potential as a novel solution for treating severe bleeding.
Synergy of engineered gelatin methacrylate-based porous microspheres and multicellular assembly to promote osteogenesis and angiogenesis in bone tissue reconstruction.
Int J Biol Macromol
December 2024
Rapid Manufacturing Engineering Center, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China; Shanghai Key Laboratory of Intelligent Manufacturing and Robotics, Shanghai University, Shanghai 200072, China; National Demonstration Center for Experimental Engineering Training Education, Shanghai University, Shanghai 200444, China. Electronic address:
One of the key challenges in bone defects treatment is providing adequate and stable blood supply during new tissue regeneration. Mesenchymal stem cells (MSCs) and endothelial cells (ECs) have great potential to promote osteogenesis and angiogenesis during bone defect repair through paracrine effects, but their therapeutic efficacy depends on effective cellular assembly and delivery. In this work, we developed various microspheres with different pore sizes for multi-cellular delivery to enhance the angiogenic and osteogenic capability via combining microfluidic and gradient freeze-drying techniques.
View Article and Find Full Text PDFiPSC-derived megakaryocytes and platelets accelerate wound healing and angiogenesis.
Stem Cell Res Ther
October 2024
Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Background: Platelet-rich plasma (PRP), which is prepared by concentrating platelets in autologous blood, shows efficacy in chronic skin wounds via multiple growth factors. However, it exhibits heterogeneity across patients, leading to unstable therapeutic efficacy. Human induced pluripotent stem cell (iPSC)-derived megakaryocytes and platelets (iMPs) are capable of providing a stable supply, holding promise as materials for novel platelet concentrate-based therapies.
View Article and Find Full Text PDFFormulation Optimization and Characterization of Solid Lipid Nanoparticles of Apixaban.
Recent Pat Nanotechnol
August 2024
Department of Pharmaceutics, SVKM NMIMS School of Pharmacy and Technology Management, Shirpur, 425405, Dhule, India.
Background: Unpredictable situations such as clotting of blood, deep vein thrombosis, and pulmonary embolism arise in the body, which is the leading cause of mortality. Such conditions generally arise after surgery as well as after treatment with oral anticoagulant agents. Apixaban is a novel oral anticoagulant widely recommended for the prevention and treatment of strokes and blood clots suffering from nonvalvular atrial fibrillation by suppressing factor Xa.
View Article and Find Full Text PDFStudy and evaluation of a gelatin- silver oxide nanoparticles releasing nitric oxide production of wound healing dressing for diabetic ulcer.
PLoS One
June 2024
Department of Orthopedics, Dongguan Songshan Lake Tungwah Hospital, Dongguan City, Guangdong Province, China.
This study aimed to develop a novel Gelatin silver oxide material for releasing nitric oxide bionanocomposite wound dressing with enhanced mechanical, chemical, and antibacterial properties for the treatment of diabetic wounds. The gelatin- silver oxide nanoparticles (Ag2O-NP) bio nanocomposite was prepared using chitosan and gelatin polymers incorporated with silver oxide nanoparticles through the freeze-drying method. The samples were characterized using scanning electron microscopy (SEM) and X-ray diffraction (XRD) analysis.
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