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Assessment of the and Antitumor Activity of Hemocyanins from , , and in a Graffi Myeloid Tumor Model.
Biomedicines
May 2023
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria.
Hemocyanins are oxygen-transporting glycoproteins in the hemolymph of some invertebrate species that attracted scientific interest as potential anticancer agents. The present study aims to assess the and anticancer activity of hemocyanins isolated from , , and in the Graffi myeloid tumor model. The antitumor activity of the hemocyanins was determined by a MTT test and cytomorphological analysis by fluorescent and transmission electron microscopy.
View Article and Find Full Text PDFShort-term anterior chamber inflammation in phacoemulsification with and without Ex-Press glaucoma implant.
Eur J Ophthalmol
May 2020
Department of Ophthalmology, Rabin Medical Center, Beilinson Hospital, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Purpose: The aim of this study was to investigate the incidence of clinically significant anterior chamber inflammation in a combined surgery, namely, phacoemulsification and Ex-Press miniature glaucoma device implantation, compared to phacoemulsification alone.
Methods: A retrospective comparative study of a consecutive series of 210 participants above 18 years of age diagnosed with significant cataract and who required glaucoma surgery, namely, Ex-Press miniature glaucoma device implantation or cataract alone in one or both eyes. All were operated on by a single experienced glaucoma surgeon in a single medical center.
Antitumor activity of quaternized chitosan-based electrospun implants against Graffi myeloid tumor.
Int J Pharm
November 2010
Institute of Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, Acad. G. Bonchev St. bl. 25, BG-1113 Sofia, Bulgaria.
Nanofibrous implants containing quaternized chitosan (QCh), poly(L-lactide-co-D,L-lactide) (coPLA), and the antitumor drug doxorubicin (DOX) were fabricated by electrospinning. The surface chemical composition and the morphology of the implants were characterized by XPS and SEM. In vitro cell viability studies demonstrated that QCh- and DOX-based implants exhibited high cytotoxicity against Graffi tumor cells.
View Article and Find Full Text PDFComparative evaluation of techniques for the manufacturing of dendritic cell-based cancer vaccines.
J Cell Mol Med
January 2009
Laboratory of Tumour Immunology, St Anna Children's Cancer Research Institute, Vienna, Austria.
Manufacturing procedures for cellular therapies are continuously improved with particular emphasis on product safety. We previously developed a dendritic cell (DC) cancer vaccine technology platform that uses clinical grade lipopolysaccharide (LPS) and interferon (IFN)-y for the maturation of monocyte derived DCs. DCs are frozen after 6 hrs exposure at a semi-mature stage (smDCs) retaining the capacity to secret interleukin (IL)-12 and thus support cytolytic T-cell responses, which is lost at full maturation.
View Article and Find Full Text PDFProtective effect of Astragalus corniculatus saponins against myeloid graffi tumour in hamsters.
Phytother Res
March 2004
Department of Pharmacognosy, Faculty of Pharmacy, Medical University, 2 Dunav St., 1000 Sofia, Bulgaria.
A purified mixture containing mostly saponins (PMS) from Astragalus corniculatus Bieb. was used in an in vivo model to demonstrate its protective effect against myeloid Graffi tumour in hamsters. Survivability, tumour growth and tumour transplantability were followed.
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