The reliability of the diagnosis of choriocarcinoma from uterine curettings is still a matter for debate, and few pathologists see enough material for an objective clinico-pathological study. In the present survey curettings from 54 patients were examined, 38 during follow up of a hydatidiform mole, 12 following a normal pregnancy and four after a spontaneous abortion. Four histological categories were identified: villous, simple trophoblast, trophoblast with appearances suspicious of choriocarcinoma, and trophoblast diagnostic of choriocarcinoma. The presence of hydropic villi is evidence that malignant change has not developed at that time and only two of the 20 patients in this group subsequently developed choriocarcinoma. The interpretation of simple or suspicious trophoblast depends on the antecedent gestation: if it were molar, malignant change is relatively infrequent (choriocarcinoma subsequently developed in four out of 15 patients); if it were non-molar then malignancy is a strong possibility (choriocarcinoma developed in nine and metastatic trophoblastic disease in four of the 13 patients). The correct management of the individual patient can only be achieved by a full consideration of the histological features together with the clinical history and findings.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC477238 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Unusual Extension of Superficial Spreading Squamous Cell Carcinoma of Cervix to Uterus, Paraovarian, Paratubal Tissue, and Vaginal Surface: A Unique Case Report.
J Midlife Health
October 2024
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bibinagar, Telangana, India.
Superficial spreading cervical squamous cell carcinoma (SCC) is a rare phenomenon with few cases reported in the literature. The present case report briefs the findings of superficial spreading cervical SCC in postmenopausal women. A 65-year-old postmenopausal woman presented with bleeding per-vaginum for 1-2 months.
View Article and Find Full Text PDFBrenner Tumor of the Ovary in a Patient With Postmenopausal Bleeding: A Case Report.
Cureus
August 2024
Department of Obstetrics, Gynecology & Reproductive Health, Rutgers University New Jersey Medical School, Newark, USA.
Article Synopsis
- Brenner tumors are types of ovarian epithelial tumors that can present as benign, borderline, or malignant, and the case discussed highlights one associated with postmenopausal bleeding and elevated estradiol levels.
- A 59-year-old woman, who had been menopausal for seven years, experienced postmenopausal bleeding and underwent various evaluations, including ultrasound and biopsies, leading to findings of a mass in the right adnexa.
- Ultimately, the patient had a laparoscopic hysterectomy which revealed the mass to be a Brenner tumor; the case emphasizes the importance of evaluating persistent postmenopausal bleeding to rule out serious conditions like endometrial cancer.
Utility of Pipet Curet Cytology and Biopsy as a Diagnostic Method for Endometrial Endometrioid Carcinoma.
Acta Cytol
November 2024
Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
Article Synopsis
- The study focused on comparing the effectiveness of Pipet Curet cytology (PCC) and Pipet Curet biopsy (PCB) for diagnosing endometrial endometrioid carcinoma (EEC) in 77 patients, categorized based on the Federation of Gynecology and Obstetrics (FIGO) grades.
- Results showed that the diagnostic sensitivity was significantly higher for advanced G2/3 EEC cases than for G1 EECs across all methods, indicating that more aggressive cancer types yield easier detection.
- The combination of both PCC and PCB improved diagnostic accuracy, suggesting that using these methods together can reduce false negatives and enhance EEC diagnosis.
Expression of the -Linked Acetylglucosamine-containing Epitope H (O-GlcNAcH) in Human Uterine Cervical Mucosa.
In Vivo
April 2024
Department of Histology-Embryology, University of Thessaly, Medical School, Larissa, Greece.
Article Synopsis
- - The study investigates the presence of O-linked N-acetylglucosamine (O-GlcNAcH) in endocervical tissues, highlighting its different expression levels in normal and diseased cells, particularly in polyps.
- - Results show that O-GlcNAcH is weakly expressed in most mucosa but more commonly found in polyps, with specific cell types like non-mucin-secreting reserve cells displaying strong staining.
- - The findings suggest that O-GlcNAcH levels can serve as a useful marker to distinguish between certain cell types in cervical tissues, indicating its potential role in assessing inflammation or pathology.
Mutation-specific Mismatch Repair-deficient Benign Endometrial Glands in Endometrial Biopsies and Curettings Are a Biomarker of Lynch Syndrome and Associate With Endometrial Carcinoma Development.
Am J Surg Pathol
July 2023
Departments of Pathology.
Endometrial carcinoma is the most common extraintestinal cancer in Lynch syndrome (LS). Recent studies have demonstrated mismatch repair (MMR) deficiency can be detected in benign endometrial glands in LS. We performed MMR immunohistochemistry in benign endometrium from endometrial biopsies and curettings (EMCs) from a study group of 34 confirmed LS patients and a control group of 38 patients without LS who subsequently developed sporadic MLH1-deficient or MMR-proficient endometrial carcinoma.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!