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Neuroprotection by Polyherbal Medicine Divya-Medha-Vati Against Scopolamine-Induced Cognitive Impairment Through Modulation of Oxidative Stress, Acetylcholine Activity, and Cell Signaling.
Mol Neurobiol
March 2024
Drug Discovery and Development Division, Patanjali Research Foundation, Uttarakhand, Haridwar, 249 405, India.
Alzheimer disease is associated with cognitive impairments and neuronal damages. In this study, Scopolamine, a model drug used for the generation of Alzheimer-like symptoms induced cognitive dysfunction in C57BL/6 mice. It also elevated acetylcholine esterase (AcHE) activity, and reduced antioxidant (superoxide dismutase and catalase) activity in cortex tissue.
View Article and Find Full Text PDFImpact of preweaning stress on long-term neurobehavioral outcomes in Sprague-Dawley rats: Differential effects of barren cage rearing, pup isolation, and the combination.
Neurotoxicol Teratol
November 2021
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, USA. Electronic address:
Two developmental stressors were compared in preweaning rats exposed to either one stressor or both. Stressors were barren cage rearing or maternal separation (pup isolation). 40 gravid Sprague-Dawley CD/IGS rats were randomly assigned to two cage conditions: standard (Std) cage or barren cage (Bar), 20 litters/condition throughout gestation and lactation.
View Article and Find Full Text PDFGhrelin increases hippocampal recombination activating gene 1 expression and spatial memory performance in mice.
Neuroreport
September 2013
Department of Clinical Medicine, School of Medicine, Zhejing University City College, Hangzhou, China.
Ghrelin, which has been shown to improve memory retention, is an endogenous ligand for the growth hormone secretagogue receptor. Recombination activating gene 1 (Rag1), which plays a critical role in the development and maturation of lymphocytes in the immune system, is also expressed in the central nervous system, particularly in the hippocampus, and has been implicated in memory formation. In the current study, the effects of ghrelin on Rag1 expression in the hippocampus and spatial memory performance in wild-type and Rag1 knockout (KO) mice were examined.
View Article and Find Full Text PDFMaternal dietary zinc supplementation prevents aberrant behaviour in an object recognition task in mice offspring exposed to LPS in early pregnancy.
Behav Brain Res
January 2009
Division of Clinical Biochemistry, Hanson Institute and Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA 5000, Australia.
Maternal infection during pregnancy is associated with an increased risk of neurodevelopmental damage. While the mechanism is unclear accumulating evidence suggests that the maternal inflammatory response may be responsible. Metallothionein (MT) is a zinc (Zn)-binding protein that when induced in the mother's liver during the acute phase response has been found to cause a fetal Zn deficiency.
View Article and Find Full Text PDFDietary zinc supplementation during pregnancy prevents spatial and object recognition memory impairments caused by early prenatal ethanol exposure.
Behav Brain Res
January 2008
Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia.
Alcohol-induced zinc (Zn) deficiency is one of the mechanisms proposed as a cause of ethanol teratogenicity. Subcutaneous Zn treatment with ethanol in early pregnancy has been shown to prevent birth abnormalities and memory impairments in mice. This study examined whether dietary Zn supplementation throughout pregnancy can prevent cognitive impairments caused by early ethanol exposure.
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