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Intestinal parasitic infections among children aged 7-14 years in Mizan-Aman city, Southwest Ethiopia: a community-based cross-sectional study.
Front Public Health
January 2025
School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, Ethiopia.
Background: Intestinal parasitic infections continue to pose a major threat to human health globally, with a particularly high prevalence in developing countries. Soil-borne helminthiasis and schistosomiasis are notably widespread.
Objective: The objective of the study was to determine the prevalence and contributing factors of intestinal parasites infection among participants aged 7-14 years.
Evaluating the Immunoprotective and Diagnostic Potential of Schistosoma mansoni Epitopes from Sm050890 and Sm141290 Proteins Identified Through Reverse Vaccinology.
Acta Parasitol
January 2025
Federal University of São João del-Rei, Divinópolis, MG, Brazil.
Purpose: Schistosomiasis remains a parasitic disease affecting millions of people worldwide, requiring interventions like vaccination. In previous work, our group used reverse vaccinology to identify two epitopes from the Schistosoma mansoni proteins, Sm050890 (44-58) and Sm141290 (225-239). This study evaluated the immune response profile and protection induced by peptides, as a mixture of immunogens, in murine vaccination trials.
View Article and Find Full Text PDFDevelopment and Application of an In Vitro Drug Screening Assay for Schistosomula Using YOLOv5.
Biomedicines
December 2024
Infectious and Tropical Diseases Research Group (e-INTRO), Biomedical Research Institute of Salamanca, Research Centre for Tropical Diseases at the University of Salamanca (IBSAL-CIETUS), Faculty of Pharmacy, University of Salamanca, 37007 Salamanca, Spain.
Background: Schistosomiasis impacts over 230 million people globally, with 251.4 million needing treatment. The disease causes intestinal and urinary symptoms, such as hepatic fibrosis, hepatomegaly, splenomegaly, and bladder calcifications.
View Article and Find Full Text PDFGenomic basis of schistosome resistance in a molluscan vector of human schistosomiasis.
iScience
January 2025
Program in Public Health, College of Health Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Freshwater snails are obligate intermediate hosts for the transmission of schistosomiasis, one of the world's most devastating parasitic diseases. To decipher the mechanisms underlying snail resistance to schistosomes, recombinant inbred lines (RILs) were developed from two well-defined homozygous lines (iM line and iBS90) of the snail . Whole-genome sequencing (WGS) was used to scan the genomes of 46 individual RIL snails, representing 46 RILs, half of which were resistant or susceptible to .
View Article and Find Full Text PDFAnthelmintic Potential of Conjugated Long-Chain Fatty Acids Isolated from the Bioluminescent Mushroom .
J Nat Prod
January 2025
Department of Chemistry, Federal University of Piaui, Campus Ministro Petrônio Portela, Teresina, PI 64049-550, Brazil.
With praziquantel being the sole available drug for schistosomiasis, identifying novel anthelmintic agents is imperative. A chemical investigation of the fruiting body of the bioluminescent mushroom Berk. resulted in the isolation of new conjugated long-chain fatty acids (8,10,12,13)-12,13-dihydroxy-7-oxo-octadeca-8,10-dienoic acid () and (7,8,9,11)-7,8-dihydroxy-13-oxo-octadeca-9,11-dienoic acid () and three previously described compounds, (7,8,9)-7,8-dihydroxyoctadec-9-enoic acid (), (2)-dec-2-ene-1,10-dioic acid (), and a ketolactone marasmeno-1,15-dione ().
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