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Eastern Equine Encephalitis Virus: The Importance of Metabolism and Aging.
Int J Mol Sci
December 2024
Department of Preclinical and Basic Sciences, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 87-100 Torun, Poland.
Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus that, among humans, can cause a severe and often fatal illness. The zoonotic EEEV enzootic cycle involves a cycle of transmission between and avian hosts, frequently resulting in spillover to dead-end vertebrate hosts such as humans and horses. Interestingly, it has been described that the W132G mutation of the very low-density lipoprotein receptor (VLDLR), the receptor of EEEV, significantly enhanced the VLDLR-mediated cell attachment of EEEV.
View Article and Find Full Text PDFA New Variant of Avian Encephalomyelitis Virus Associated with Neurologic Signs in Turkey Poults.
Pathogens
September 2024
Animal Disease Research and Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007, USA.
Avian encephalomyelitis (AE) is a disease caused by the avian encephalomyelitis virus (AEV) of the genus Tremovirus in the family Picornaviridae. Recently, cases of turkey poults showing neurological signs were submitted to the veterinary diagnostic laboratories at South Dakota State University and the University of Minnesota. The affected birds were showing nervous neurological signs such as tremors, inability to stand, torticollis, and wing drop.
View Article and Find Full Text PDFPossible manufacture of test allergens in public pharmacies for the diagnosis of type I allergies: Legal aspects.
Allergol Select
July 2024
Allergology Division, Paul-Ehrlich-Institut (PEI), Langen (Hesse).
Article Synopsis
- * The German Medicinal Products Act (AMG) allows pharmacies to prepare medicinal products, including test allergens, without needing a marketing authorization, which could help fill the diagnostic gap.
- * The text discusses the practical and legal challenges of creating skin prick test solutions in pharmacies while exploring potential allergen sources and their implications.
Shifts in receptors during submergence of an encephalitic arbovirus.
Nature
August 2024
Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Article Synopsis
- Western equine encephalitis virus (WEEV) used to cause significant outbreaks in humans and horses but has become less virulent over time, raising questions about the reasons for this change and the potential for re-emergence of deadly strains.
- Researchers identified protocadherin 10 (PCDH10) as a key receptor for WEEV, which ancient strains could bind to, while contemporary strains show reduced binding abilities indicating a shift in the virus’s host adaptation.
- The study suggests that PCDH10 not only facilitates infection in neurons but also that a soluble form can protect against WEEV, offering insights for future medical treatments and risk assessments of the virus.
Module-combinatorial design and screening of multifunctional polymers based on polyaspartic acid for DNA delivery.
Int J Pharm
August 2024
Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Engineering Research Center of Pharmaceutical Process Chemistry, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address:
It is crucial to develop non-viral gene vectors that can efficiently and safely transfect plasmid DNA into cells. Low transfection efficiency and high cytotoxicity of cationic polymers hinder their application as gene carriers. Modification of cationic polymers has emerged as an attractive strategy for efficient and safe nucleic acids delivery.
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