Polymorphonuclear leukocytes are degranulated in the lumens of vessels in synovial membrane in humans with various types of inflammatory arthritis and in dogs with synovitis induced by urate crystals. This degranulation, accompanied by the release of lysosomal enzymes and vasoactive materials, may be an important part of the mechanism resulting in vascular injury.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1126/science.175.4026.1139 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis.
Commun Biol
July 2023
John W. Deming Department of Medicine, Tulane Eosinophilic Disorders Center (TEDC), Section of Pulmonary Diseases, Tulane University School of Medicine, New Orleans, LA, USA.
The current report describes a stepwise mechanistic pathway of NLRP3/caspase1/IL-18-regulated immune responses operational in eosinophilic esophagitis (EoE). We show that esophageal epithelial cells and macrophage-derived NLRP3 regulated IL-18 initiate the disease and induced IL-5 facilitates eosinophil growth and survival. We also found that A.
View Article and Find Full Text PDFCell-free histones and the cell-based model of coagulation.
J Thromb Haemost
July 2023
Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK; The Roald Dahl Haemostasis and Thrombosis Centre, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK. Electronic address:
The cell-based model of coagulation remains the basis of our current understanding of clinical hemostasis and thrombosis. Its advancement on the coagulation cascade model has enabled new prohemostatic and anticoagulant treatments to be developed. In the past decade, there has been increasing evidence of the procoagulant properties of extracellular, cell-free histones (CFHs).
View Article and Find Full Text PDFTethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site.
Res Pract Thromb Haemost
February 2023
Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Background: Puncture wounding is a longstanding challenge to human health for which understanding is limited, in part, by a lack of detailed morphological data on how the circulating platelet capture to the vessel matrix leads to sustained, self-limiting platelet accumulation.
Objectives: The objective of this study was to produce a paradigm for self-limiting thrombus growth in a mouse jugular vein model.
Methods: Data mining of advanced electron microscopy images was performed from authors' laboratories.
Prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoning.
Clin Exp Emerg Med
September 2022
Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Objective: Carbon monoxide (CO) activates intravascular neutrophils through platelet-neutrophil aggregates, which cause neutrophil degranulation. This process causes the release of myeloperoxidase (MPO), proteases, and reactive oxygen species. The MPO index (MPXI) is a newly reported inflammatory marker that reflects the MPO level within neutrophils.
View Article and Find Full Text PDF[A novel mouse allergy tested model and its application for traditional Chinese medicine injections's allergy evaluation].
Zhongguo Zhong Yao Za Zhi
July 2022
State Key Laboratory of Innovative Natural Medicine and Traditional Chinese Medicine Injections, Key Laboratory of Beijing for Identification and Safety of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
When the drug induces the organism to produce a type Ⅰ allergic reaction, the combination of IgE and mast cells results in the degranulation of the mast cells. Release of vasoactive substances, increase in vascular permeability, and exudation of intravascular substances outside the blood vessels. Based on this pathophysiological mechanism, a mouse model that can objectively and quantitatively assess the allergic response to the injection has been established.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!