Blood leukocytes of two species of new world primates, other than human, transform following exposure to Epstein-Barr virus. The transformed simian cells produce Epstein-Barr virus antigens and infectious (transforming) virus. The simian lymphoblastoid cells form multinucleate giant cells that appear to be selective sites for the production of Epstein-Barr virus. Multinucleate cells reveal intranuclear inclusions; in both species, a large proportion of giant cells contain Epstein-Barr virus antigen detectable by immunofluorescence.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC426463 | PMC |
| http://dx.doi.org/10.1073/pnas.69.2.383 | DOI Listing |
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