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Detection of chronic wasting disease prions in the farm soil of the Republic of Korea.
mSphere
January 2025
WOAH Reference Laboratory for CWD, Foreign Animal Disease Division, Animal and Plant Quarantine Agency, Gimcheon, South Korea.
Chronic wasting disease (CWD) is a highly contagious prion disease occurring in free-ranging and farmed cervids. CWD continues to spread uncontrolled across North America, and cases continue to be detected almost every year in the Republic of Korea. CWD-infected animals contaminate the soil by releasing infectious prions through their excreta, and shed prions accumulate and remain infectious in the soil for years.
View Article and Find Full Text PDFThe Mechanism of Acupuncture Therapy for Migraine: A Systematic Review of Animal Studies on Rats.
J Pain Res
January 2025
Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, People's Republic of China.
Background: Acupuncture has long been used for migraine treatment as it is convenient for use and has remarkable efficacy. The acupuncture-based comprehensive treatment plan has been widely recognized for migraine prevention and treatment. However, the mechanism underlying acupuncture efficacy in migraine treatment is not yet completely understood.
View Article and Find Full Text PDFThe Potential Proallergenic Activity of and in vitro Studies.
J Inflamm Res
January 2025
Department of Virology and Immunology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Lublin, Poland.
Purpose: Allergic diseases have escalated to epidemic levels worldwide, impacting nearly 30% of the global population. Fungi are a significant source of allergens responsible for up to 6% of respiratory diseases in the general population. However, the specific cause of respiratory allergies often remains unidentified.
View Article and Find Full Text PDFAnalysis of engineered T7 bacteriophages containing genetic sequences encoding antimicrobial peptides.
Front Antibiot
January 2025
Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, Center for Biotechnology and Biomedicine, Leipzig University, Leipzig, Germany.
Because of the global spread of multi- and pan-resistant bacteria, there is a need to identify, research, and develop new strategies to combat these pathogens. In a previous proof-of-concept study, we presented an innovative strategy by genetically modifying lytic T7 bacteriophages. We integrated DNA fragments encoding for derivatives of the antimicrobial peptide (AMP) apidaecin into the phage genome to induce the production and release of apidaecin within the T7 infection cycle, thereby also targeting phage-resistant bacteria.
View Article and Find Full Text PDFThe representation of stimulus features during stable fixation and active vision.
J Neurosci
January 2025
The Department of Psychology and The Department of Cognitive and Brain Sciences, The Hebrew University of Jerusalem.
Predictive updating of an object's spatial coordinates from pre-saccade to post-saccade contributes to stable visual perception. Whether object features are predictively remapped remains contested. We set out to characterise the spatiotemporal dynamics of feature processing during stable fixation and active vision.
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