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Wieacker-Wolff syndrome with hyperinsulinemic hypoglycemia successfully treated using diazoxide: A case report.
Clin Pediatr Endocrinol
January 2025
Department of Pediatrics, The University of Tokyo, Tokyo, Japan.
Wieacker-Wolff syndrome (WRWF) is an X-linked genetic disorder characterized by neuromusculoskeletal abnormalities caused by loss-of-function variants of the gene. Here, we report the case of a male infant with WRWF manifesting as multiple joint contractures and congenital anomalies at birth. He underwent gastrostomy to treat the gastroesophageal reflux disease, which caused mixed apnea and transient bradycardia.
View Article and Find Full Text PDFMeningeal K ATP channels contribute to behavioral responses in preclinical migraine models.
Pain
February 2025
Department of Neuroscience, The Center for Advanced Pain Studies, The University of Texas at Dallas, Richardson, TX, United States.
Human experimental studies have shown that levcromakalim, an ATP-sensitive potassium (K ATP ) channel opener, induces migraine attacks in people with migraine but not in healthy volunteers. However, the exact site of action for K ATP channels in migraine pathophysiology remains unclear. This study investigates the role of these channels in the meninges in eliciting behavioral hypersensitivity responses in mice.
View Article and Find Full Text PDFAwareness of Hypoglycemic Episodes Among Patients With Type 2 Diabetes Mellitus in Aseer Region, Saudi Arabia: A Cross-Sectional Study in 2024.
Cureus
October 2024
Endocrinology and Metabolism, King Abdulaziz Medical City, Riyadh, SAU.
Background Hypoglycemia, where blood glucose is ≤70 mg/dL, is a serious diabetic complication with high individual and community costs. This study aimed to investigate the level of awareness of hypoglycemic episodes among type 2 diabetic patients in the Aseer region, Saudi Arabia. Methods This cross-sectional study was conducted in the Aseer region of Saudi Arabia over 9 months, among 235 type 2 diabetic patients.
View Article and Find Full Text PDFAntidiabetic Medication and Asthma Attacks.
JAMA Intern Med
January 2025
National Heart and Lung Institute, Imperial College London, London, England.
Importance: Elevated body mass index (BMI) and type 2 diabetes are prevalent in asthma and are associated with an increase in the risk of asthma attacks. In experimental studies, the diabetes medications metformin and glucagon-like peptide-1 receptor agonists (GLP-1RA) have mitigated airway inflammation, hyperresponsiveness, and remodeling. However, epidemiological evidence is limited.
View Article and Find Full Text PDFCardiovascular Risks With SGLT2 Inhibitors in Clinical Practice Among Patients With Type 2 Diabetes.
JAMA Netw Open
October 2024
Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Article Synopsis
- This study investigates the impact of SGLT2 inhibitors (SGLT2i) compared to DPP4 inhibitors (DPP4i) on cardiovascular disease (CVD) events in patients with type 2 diabetes (T2D), focusing on how effective these treatments are in real-world clinical settings.
- Conducted at a leading medical center in Taiwan, the research analyzed data from adult T2D patients who started on either SGLT2i or DPP4i drugs between 2016 and 2019, with follow-ups extending up to six years to assess total CVD occurrences and specific types of CVD events.
- Results showed that SGLT
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