In the combined irradiation (the total dose of the thyroid uptake--15000 rad) the total incidence of tumors was close to that in isolated X-irradiation, but their multiplicity was much higher. The incidence of thyroid tumors (16.6%) was close to that in iodine-131 administration (17.7%, the absorbed dose--11000 rad) and x-irradiation (17.5%).
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The test for somatic mutagenesis and recombination in Drosophila is one of the widely used approaches for determination of possible carcinogenic effects of chemical compounds. The use of heterozygotes for mutant tumor suppressor gene wts enables more direct evaluation of the blastomogenic effects of chemical compounds, by tumor formation in the adult flies. This study presents evaluation of the SMART effectiveness upon the use of Drosophila heterozygotes for the wts(P4) gene, first included into the test system.
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