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Objective: To evaluate the correlation between ATP-binding cassette (ABC) transporter expression and therapeutic efficacy of enfortumab vedotin (EV), an antibody-drug conjugate targeting Nectin-4, in urothelial cancer, as only a few studies have been conducted on this topic.
Patients And Methods: This retrospective study included 20 patients with metastatic urothelial carcinoma (mUC), including bladder and upper urinary tract cancers, who were treated with EV at Dokkyo Medical University Hospital between 2022 and 2024. Immunohistochemical staining was performed on formalin-fixed, paraffin-embedded tissue samples.
Development and Validation of a Competitive Risk Model in Elderly Patients with Transitional Cell Bladder Carcinoma.
Med Sci Monit
January 2025
Department of Urology, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, Zhejiang, China.
BACKGROUND Transitional cell bladder carcinoma (tcBC) is the predominant form of bladder cancer, making up around 95% of reported cases. Prognostic factors for older individuals with tcBC differ from those affecting younger patients. The main purpose of this study was to establish a prognostic competing risk model for elderly patients with tcBC.
View Article and Find Full Text PDFNon-invasive diagnosis for urothelial carcinoma using a dual-target DNA methylation biomarker panel.
Clin Chim Acta
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Department of Urology, The People's Hospital of Qingyang City/Qingyang Hospital of the Second Hospital of Lanzhou University, Qingyang 745000 China. Electronic address:
Background: Urothelial carcinoma (UC) is a common malignancy worldwide. Aberrant DNA methylation is implicated in UC carcinogenesis. This study sought to delineate the DNA methylation landscape in UC and identify DNA methylation-based biomarkers for early detection of UC.
View Article and Find Full Text PDFLaparoscopic treatment of perineal hernia after previous abdominal perineal rectal resection due to cancer. Case report.
Wiad Lek
January 2025
DEPARTMENT OF GENERAL, ONCOLOGICAL AND DIGESTIVE TRACT SURGERY, MEDICAL CENTRE OF POSTGRADUATE EDUCATION, ORŁOWSKI HOSPITAL, MEDICAL CENTRE OF POSTGRADUATE EDUCATION, WARSAW, POLAND.
The aim of this study is to present a case of laparoscopic treatment of perineal hernia in a patient after abdominoperineal resection od the rectum. We present the case of a 63-year-old woman who was operated on laparoscopically with a mesh sewn in at the level of the sacrum, iliac vessels and pubic symphysis. And covered with a peritoneal flap above the urinary bladder.
View Article and Find Full Text PDFImmunohistochemical evaluation of SOX-10 in patients with urinary bladder cancer.
Wiad Lek
January 2025
DEPARTMENT OF GENERAL PATHOLOGY AND FORENSIC MEDICINE, COLLEGE OF MEDICINE, UNIVERSITY OF KUFA, KUFA, IRAQ.
Objective: Aim: To evaluate the expression levels of SOX-10 in tissues of bladder tumor and to prove the correlation between SOX-10 expression and clinicopathological characteristics of bladder tumors, including patient age, sex, tumor grade, and muscle invasion.
Patients And Methods: Materials and Methods: Forty formalin fixed paraffin embedded FFPE tissue blocks gathered by transurethral resection of bladder tumor are collected from teaching hospitals at Al-Najaf governorate. Those blocks were stained by hematoxylin and eosin.
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