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AFAP targets the host nucleolus and inhibits induced apoptosis.
Front Microbiol
January 2025
Laboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.
, the etiologic agent of human granulocytic anaplasmosis (HGA), is an obligate intracellular Gram-negative bacterium. During infection, transfers its type IV secretion system (T4SS) effector proteins into host cells to manipulate cellular processes. AFAP (an actin filament-associated protein) was identified as a T4SS effector protein and found to interact with the host nucleolin, as described in a previous study.
View Article and Find Full Text PDFIdentification of CDKN3 overexpression as a marker of poor prognosis and potential therapeutic target in low-grade glioma.
Sci Rep
January 2025
Biobank, Linyi People's Hospital, Linyi, 276003, China.
Low-grade glioma (LGG) is a primary, slow-growing brain tumor; however, its treatment and prognosis remain challenging. In this study, we analyzed cancer data from the TCGA database, focusing particularly on the expression of the CDKN3 gene in LGG. The results showed that high CDKN3 expression in LGG patients was significantly associated with poor survival outcomes.
View Article and Find Full Text PDFIdentification of scavenger receptor (LmSRA3) gene and its immune response to Aeromonas veronii in Lateolabrax maculatus.
Dev Comp Immunol
January 2025
Key Laboratory of South China Sea Fishery Resources Exploitation and Utilization, Ministry of Agriculture and Rural Affairs, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China; Sanya Tropical Fisheries Research Institute, Sanya, China. Electronic address:
Scavenger receptors (SRs) serve as essential pattern recognition receptors in the innate immune system, playing multiple roles in the immunity of fish. They contribute to defense mechanisms against pathogenic infections through various pathways. However, research on the functions of SRs in the immune response of Spotted sea bass remains limited.
View Article and Find Full Text PDFA generalizable normative deep autoencoder for brain morphological anomaly detection: application to the multi-site StratiBip dataset on bipolar disorder in an external validation framework.
Artif Intell Med
January 2025
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
The heterogeneity of psychiatric disorders makes researching disorder-specific neurobiological markers an ill-posed problem. Here, we face the need for disease stratification models by presenting a generalizable multivariate normative modelling framework for characterizing brain morphology, applied to bipolar disorder (BD). We used deep autoencoders in an anomaly detection framework, combined for the first time with a confounder removal step that integrates training and external validation.
View Article and Find Full Text PDFMeRIP-seq data analysis and validation reveal the regulatory role of mA modified circRNAs in the apoptosis of secondary hair follicle cells in Inner Mongolia cashmere goats.
Comp Biochem Physiol Part D Genomics Proteomics
January 2025
College of Life Sciences, Inner Mongolia Agricultural University, Hohhot 010010, China; Inner Mongolia Autonomous Region Key Laboratory of Biomanufacturing, Hohhot 010010, China. Electronic address:
As a widely epigenetic modification, mA (N-methyladenosine, mA) can regulate the degradation, translation, and other biological functions of circRNAs through dynamic reversible processes. It plays an important role in regulating the life activities of biological organisms, particularly in cell differentiation, apoptosis, embryonic development, stress response, and innate immunity. In this study, bioinformatics analysis, qRT-PCR identification, FISH subcellular localization, and ceRNA network construction were performed on mA modified circRNAs regulating the apoptosis of secondary hair follicle cells of Inner Mongolia Albas white cashmere goats based on the skin mA sequencing data of secondary hair follicles in anagen and catagen.
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