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Decoding the rhythmic representation and communication of visual contents.
Trends Neurosci
January 2025
Neural Computation Group, Department of Mathematics and Computer Science, Physics, Geography, Justus-Liebig-Universität Gießen, Gießen 35392, Germany; Center for Mind, Brain and Behavior (CMBB), Philipps-Universität Marburg, Justus-Liebig-Universität Gießen & Technische Universität Darmstadt, Marburg 35032, Germany. Electronic address:
Rhythmic neural activity is considered essential for adaptively modulating responses in the visual system. In this opinion article we posit that visual brain rhythms also serve a key function in the representation and communication of visual contents. Collating a set of recent studies that used multivariate decoding methods on rhythmic brain signals, we highlight such rhythmic content representations in visual perception, imagery, and prediction.
View Article and Find Full Text PDFDevelopment of TAR-200: A novel targeted releasing system designed to provide sustained delivery of gemcitabine for patients with bladder cancer.
Urol Oncol
January 2025
Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Milan, Italy; Department of Medical Oncology, IRCCS San Raffaele University, Milan, Italy.
Treatment options for recurrent high-risk non-muscle-invasive bladder cancer (HR NMIBC) and muscle-invasive bladder cancer (MIBC) are limited, highlighting a need for clinically effective, accessible, and better-tolerated alternatives. In this review we examine the clinical development program of TAR-200, a novel targeted releasing system designed to provide sustained intravesical delivery of gemcitabine to address the needs of patients with NMIBC and of those with MIBC. We describe the concept and design of TAR-200 and the clinical development of this gemcitabine intravesical system in the SunRISe portfolio of studies.
View Article and Find Full Text PDFImpact of Fli1 deletion on B cell populations: A focus on age-associated B cells and transcriptional dynamics.
J Dermatol Sci
December 2024
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan; Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:
Background: Altered Fli1 expression is associated with various autoimmune diseases, yet its impact on B cells remains unexplored.
Objective: This study investigated the direct effects of Fli1 depletion on B cell populations, focusing on age-associated B cells (ABCs).
Methods: Splenocytes of Fli1 BcKO (Cd19-Cre; Fli1) and Cd19-Cre mice were analyzed flow cytometrically.
The hidden weavers: A review of DNA/RNA R-loops in stem cell biology and therapeutic potential.
Int J Biol Macromol
January 2025
Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou 510280, Guangdong, China. Electronic address:
R-loops, three-stranded nucleic acid structures composed of RNA-DNA hybrids, are increasingly recognized as central regulators of genomic stability and transcription. These structures play critical roles across various cellular processes, including DNA replication, repair, and gene regulation, with significant implications for stem cell biology and disease pathogenesis. This review comprehensively explores the molecular underpinnings of R-loop formation, emphasizing the dual nature of R-loops in both facilitating normal cellular functions and contributing to genomic instability.
View Article and Find Full Text PDFTowards healthy sleep environments: Ambient, indoor, and personal exposure to PM and its implications in children's sleep health.
Environ Res
January 2025
Department of Civil, Environmental, & Architectural Engineering, Worcester Polytechnic Institute, Worcester, MA, United States. Electronic address:
The growing impact of climate change and escalating wildfire seasons has led to heightened ambient air pollution, potentially affecting children's sleep health. However, current epidemiological research often relies on outdoor weather data to model the environmental impacts on sleep health, potentially mischaracterizing the actual bedroom environment. To address these challenges, we conducted experiments to investigate the relationships among ambient, indoor, and personal exposure to PM concentrations and obstructive sleep apnea (OSA) in children.
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