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Aerobic exercise regulates gut microbiota profiles and metabolite in the early stage of Alzheimer's disease.
FASEB J
January 2025
Department of Neurology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Aerobic exercise (AE) has been shown to offer significant benefits for Alzheimer's disease (AD), potentially influencing the gut microbiota. However, the impact of changes in intestinal flora in early Alzheimer's disease induced by aerobic exercise on metabolic pathways and metabolites is not well understood. In this study, 3-month-old APP/PS1 and C57BL/6 mice were divided into two groups each: a control group (ADC for APP/PS1 and WTC for C57BL/6) and an aerobic exercise group (ADE for APP/PS1 and WTE for C57BL/6).
View Article and Find Full Text PDFGSDMB modulates intestinal epithelial homeostasis via regulating hyperactive unfolded protein response in Crohn's disease.
J Crohns Colitis
January 2025
Medical School of Nanjing University, Department of General Surgery, Jinling Hospital, Nanjing 210002, China.
Background: Impaired intestinal epithelial barrier has been considered to be associated with an increasing variety of gastrointestinal diseases, especially inflammatory bowel disease (IBD) encompassing Crohn's disease (CD) and ulcerative colitis (UC). We aimed to investigate the role of Gasdermin B (GSDMB) in modulating intestinal epithelial barrier integrity and proposed a promising therapeutic strategy.
Methods: GSDMB expression was evaluated in adult CD samples by molecular biology means and single-cell transcriptomes.
The impact of a high-carbohydrate diet on the cognitive behavior of mice in a low-pressure, low-oxygen environment.
Food Funct
January 2025
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
The effectiveness of high-carbohydrate diets (HCD) on cognitive impairment is still being debated. To clarify the impact of HCD on the cognitive behavior of mice under low-pressure hypoxic conditions, we studied 24 mice in different environments while subjecting them to dietary intervention for 5 weeks, and conducting behavioral tests. Under low-pressure hypoxic conditions, HCD intervention reversed the decline in spatial learning and memory abilities in mice caused by hypoxia, ameliorated pathological brain damage, and restored the integrity of the intestinal mucosa.
View Article and Find Full Text PDFPreparation of protein and its preventive effect on nonalcoholic fatty liver disease in mice.
Food Funct
January 2025
Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, 201403, China.
is a valuable edible fungus with multidimensional bioactivities; however, research on protein and its beneficial effects on nonalcoholic fatty liver disease (NAFLD) have been limited. In this study, protein (MEP) with 80.59% protein content was prepared, isolated, and characterized by the complete amino acid composition.
View Article and Find Full Text PDFChemical Composition of Royle Ex Wight and Its Potential Role in Ameliorating Colitis.
Food Sci Nutr
January 2025
State Key Laboratory of Tea Plant Biology and Utilization, School of Tea & Food Science and Technology Anhui Agricultural University Hefei Anhui P.R. China.
Royle ex Wight, commonly known as "Baishouwu," has been traditionally used in China for its medicinal and dietary benefits. Despite its long history of use, the potential therapeutic effects of in the treatment of colitis have not been fully investigated. This study aims to evaluate the effects of the water extract of root on colitis and elucidate its potential mechanisms of action.
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